Research

The following headlines link to summaries of research published in recent years. Using the filters in the navigation bar, you can filter the summaries by research area, disease or lab group.

  • Genome fingerprinting

    Ultrafast Comparison of Personal Genomes

    ISB researchers have created a method for summarizing a personal genome as a “fingerprint.”

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  • P100 Cover

    Pioneer 100 Study Establishes Foundation for New Industry of Scientific Wellness

    ISB and Arivale recently announced results from the Pioneer 100 Wellness Project, a nine-month study of 108 individuals. The results demonstrated that combining personal, dense, dynamic data clouds with tailored behavioral coaching can optimize wellness for individuals.

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  • Warhol style Plasmodium

    Identification of the proteins in Plasmodium vivax provide new targets for a malaria vaccine

    Scientists from ISB and the Center for Infectious Disease Research led an international collaboration to identify proteins in the malaria parasite Plasmodium vivax. P.

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  • Adaptive Prediction of Yeast

    How Microbes Learn to Predict the Future

    Like plants and animals, even microbes can anticipate and prepare in advance for future changes in their environment
    Similar to how Pavlov trained a dog to anticipate food when it heard a bell, ISB researchers trained yeast to anticipate a lethal toxin when it sensed caffeine
    The study revealed how in a very short period of time yeast can evolve to ‘learn’ and ‘predict’ new patterns in their environment

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  • TCGA Researchers Identify Potential Drug Targets for Leading Form of Deadly Liver Cancer

    Liver cancer is the second most common cause of death from cancer worldwide.
    ISB researchers and colleagues from The Cancer Genome Atlas Research Network performed the first large-scale, multi-platform analysis of hepatocellular carcinoma, the predominant form of liver cancer.

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  • A Cell-Surface Membrane Protein Signature for Glioblastoma

    Using integrated protein and gene expression data, ISB researchers developed a 33-gene signature for glioblastoma, an aggressive form of brain cancer.

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  • ISB Scientists Have Discovered When and Why a Microbial Community Might Collapse

    Researchers at Institute for Systems Biology have developed a framework for assessing the “health” of a microbial community through a stress test that enables them to ask when and why microbial communities collapse under different environmental conditions.

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  • Novel clustering algorithm identifies functional mutations in cancer genes

    In a study published in PLoS Computational Biology, researchers at Institute for Systems Biology (ISB) have developed a multiscale mutation clustering algorithm (M2C) that identifies variable length regions with high mutation density in cancer genes.

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  • Mapping the early effects of the Huntington’s disease mutation in mice

    A multi-institute collaboration sought to map in high-resolution the earliest effects of the Huntington’s disease mutation in mice.

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  • Introduce One-cell Doubling Evaluation of Living Arrays of Yeast! ODELAY!

    Genes, Genomes, Genetics, scientists at Institute for Systems Biology introduce ODELAY, a powerful automated and scalable growth analysis platform that uses time-lapse microscopy to photograph individual yeast cells growing into colonies.

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  • Predicting Cell Fate Decisions Using Single-Cell Analysis and the Theory of Tipping Points

    ISB researchers developed a new theory to exploit burgeoning single-cell molecular profiling measurements to make predictions of future cell behaviors.

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  • Proteomics: Identifying Organ-Specific Blood Biomarkers for Acute Liver Injury

    To assess probable injury to an organ, it is important to monitor biologic materials that originate exclusively or primarily in that organ, in this case, liver-enriched proteins.

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  • Quantitating the Complete Human Proteome

    ISB scientists collaborate with ETH Zurich to develop the Human SRMAtlas, a compendium of mass spectrometry assays for any human protein.

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  • Stitching Together Insight For Deadly Brain Cancer Glioblastoma

    Using data from TCGA and ENCODE, ISB researchers developed an integrative database and analysis platform that provides insight into the underpinnings of glioblastoma multiforme.
    Researchers developed a way to intelligently discover combinations of small RNA molecules and drugs that can lead to synergistic effects.

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  • Speeding Up Drug Discovery to Fight Tuberculosis

    Researchers at the Institute for Systems Biology and Center for Infectious Disease Research have deciphered how the human pathogen Mycobacterium tuberculosis is able to tolerate the recently approved FDA drug
    The study demonstrated that silencing certain regulatory genes in the bacteria, or pairing with a second drug pretomanid, disrupts a tolerance gene network to improve efficacy of killing by bedaquiline.
    This systems-approach to rational drug discovery represents significant advance in the fight against tuberculosis, which affects a third of the global population, surpassing HIV/AIDS in the number of deaths worldwide.

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  • Contribute

    Integrative Study of Rare Adrenocortical Carcinoma Reveals Prognostic Molecular Subtypes

    Adrenocortical carcinoma (ACC) is a rare endocrine cancer with limited therapeutic options and overall poor outcome. In TCGA (The Cancer Genome Atlas) research published on May 9, 2016, in the journal Cancer Cell, scientists, including several from Institute for Systems Biology, comprehensively analyzed 91 ACC specimens from four continents using state-of-the-art genomic technologies and computational methods.

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  • Scratching the Surface of the Malaria Parasite

    Surface coat proteins on Plasmodium, the parasite that causes malaria, provide new targets for a malaria vaccine. ISB scientists collaborate with scientists from Center for Infectious Disease Research and Johns Hopkins University to identify new proteins on the surface of the malaria parasite Plasmodium.

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  • Genomic Architecture of Inflammatory Bowel Disease in 5 Families with Multiple Affected Individuals

    In medical genetics it is an unsolved question to what degree complex diseases (such as inflammatory bowel disease) are influenced by rare variants with potentially large effects in relation to the many common and weak-effect variants that have been identified in genome-wide association studies (GWAS).
    By analyzing whole-genome sequences of five families with a high burden of inflammatory bowel disease (IBD) we aimed to elucidate the genomic architecture of IBD.

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  • Ötzi the Iceman: Helicobacter pylori Pathogen Found in Stomach Contents

    Institute for Systems Biology collaborates with researchers worldwide to study pathogens in the stomach content and microbiome of the 5300 year old European Copper Age glacier mummy “Ötzi” and discovers a Helicobacter pylori pathogen genome.
    Ötzi harbored a nearly pure Asian-origin bacterial population of H.

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  • Microalgae As Biofactories of a Sustainable Future

    In an effort to better understand the gene regulatory and metabolic networks of the single-celled alga Chlamydomonas reinhardtii, researchers at Institute for Systems Biology studied the changes in Chlamy’s genetics and metabolism that cause them to capture and store carbon dioxide.

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  • Progress & Opportunities for Metabolic Reconstruction

    In this study, we looked for evidence of such convergence through comparative analysis of 12 genome-scale yeast models.

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  • Prostate Cancer Study Identifies Numerous Subtypes of the Disease

    Prostate cancer is the second most common cancer in men worldwide. The clinical behavior of prostate cancer is variable with some men exhibiting indolent prostate cancer which can be monitored over time while other men develop aggressive prostate cancer which can lead to metastasis and death.

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  • A Multilevel Pan-cancer Map Links Gene Mutations to Cancer Hallmarks

    In the scientific community, cancer is not considered a single disease but a multitude of diseases. Different genes and molecular pathways have been associated with different types of cancer.

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  • Researchers determine architecture of a macromolecular complex regulating gene expression and DNA repair

    The expression, or transcription, of genes controls the identity and function of a cell. DNA damage caused by UV light or other carcinogens must be repaired to maintain genome integrity.

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  • Project Feed 1010 – Sustainable Agriculture

    We are in the throes of the sixth mass extinction on our planet. Whereas 9 species were predicted to go extinct since 1900, more than 450 have gone extinct, with mammals disappearing at the highest rate.

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  • 100K Wellness Project

    The Institute for Systems Biology (ISB) pioneered and has been recognized as the world leader in the systems approach to studying biology for the past 15 years. Guided by the vision of Dr.

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  • ISB-CGC banner image

    Cancer Genomics Cloud

    The ISB Cancer Genomics Cloud:
    Leveraging Google Cloud Platform for TCGA Analysis
    The ISB Cancer Genomics Cloud (ISB-CGC) is one of three pilot projects funded by the National Cancer Institute with the goal of democratizing access to the TCGA data by substantially lowering the barriers to accessing and computing over this rich dataset. The ISB-CGC is a cloud-based platform that will serve as a large-scale data repository for TCGA data, while also providing the computational infrastructure and interactive exploratory tools necessary to carry out cancer genomics research at unprecedented scales.

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  • A Mixture of Markers from Two Distinct Cell Types Indicates Poor Prognosis in Breast Cancer

    Metastatic breast cancer remains an incurable disease and has stimulated the search for the most aggressive cell types in the tumors that drive metastasis. These cells have long been thought to possess stem-cell character, hence the idea of Cancer Stem Cells, or CSCs.

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  • Genetic Switch May Help Marine Microalgae Respond to Higher CO2 Levels

    Rapid climate change, including ocean acidification caused by increasing carbon dioxide (CO2) levels, is predicted to affect the oceans, sea life, and the global carbon cycle.
    Marine microalgae, including diatoms, are responsible for converting CO2 into oxygen and biologically usable carbon through photosynthesis.

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  • Scanning EM of bacteria being eaten by white blood cell Photo Credit: Adrian Ozinsky

    Most Powerful Tool for Reconstructing a Gene Network

    Nearly a decade ago, ISB’s Baliga Lab published a landmark paper describing cMonkey, an innovative method to accurately map gene networks within any organism from microbes to humans.
    Two new papers describe the benchmark results of cMonkey and also the release of cMonkey2, which performs with higher accuracy.

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  • A Global Map To Fight Tuberculosis

    The disease progression of tuberculosis is extremely complex and it’s poorly understood.
    ISB and Seattle BioMed researchers have made an important step by developing a comprehensive map of gene regulation in tuberculosis.

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  • ISB Launches 3-Year Wilke Lyme Disease Project

    Study Utilizes Systems Approaches to Develop Diagnostics and Deeper Understanding of Chronic Lyme. ISB has received $2.

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  • ISB Releases Open-Source Software to Analyze Digital Fingerprint of Protein Data

    SWATH mass spectrometry, an emerging protein analysis technique being pioneered by ISB researchers, provides a digital fingerprint of all accessible proteins in a sample.
    The data generated by the SWATH technique are highly complex and require sophisticated computational tools in order to extract identities from a sea of data.

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  • Identifying markers of healthy skin development

    The barrier function of skin is integral to personal well-being and is associated with several widespread diseases such as eczema and psoriasis.
    ISB and Procter & Gamble researchers used human skin grown in the lab to measure changes in protein levels as the skin matures.

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  • Found: Key Protein Tied to ‘Good’ Cholesterol

    Inflammation causes cholesterol buildup and leads to cardiovascular disease, the leading cause of death in the world
    ISB, Seattle Biomed, and Oregon State University researchers collaborate to identify a compendium of proteins that control expression of a key regulator of cholesterol efflux
    Targeting cholesterol efflux to HDL is a potentially important therapeutic strategy for preventing and treating cardiovascular disease

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  • A Universe Under the Microscope

    It may seem strange to begin a prognostication for microbiology with a quote from an astronomer, but the two topics are more closely linked than appears at first glance. For starters, both fields were revolutionized around the same time, in the 17th century, with drastic improvements to the telescope and the compound microscope.

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  • Understanding the Genetic ‘Architecture’ of Bipolar Disorder

    Bipolar disorder (BD) is a common, severe and recurrent psychiatric disorder with no known cure and substantial morbidity and mortality. Heritable causes contribute up to 80 percent of lifetime risk for BD.

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  • Network Representations of Immune System Complexity

    The mammalian immune system is a dynamic multiscale system composed of a hierarchically organized set of molecular, cellular, and organismal networks that act in concert to promote effective host defense. These networks range from those involving gene regulatory and protein–protein interactions underlying intracellular signaling pathways and single-cell responses to increasingly complex networks of in vivo cellular interaction,

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  • ISB Releases Kaviar, World’s Largest Public Catalog of Human Genomic Variation

    Kaviar is ISB’s comprehensive catalog of human genomic variation
    Kaviar combines 31 data sources for a total of 151 million single nucleotide variants (SNVs), covering 5% of all the positions in the human genome
    A researcher studying possible disease-causing variants can use Kaviar to answer the question, “Have these variants been observed before, and if so, how often?”

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  • Into the Genetic Weeds of Hair Growth

    ISB researchers used a data-driven mathematical model to identify specific genes associated with hair regeneration.
    Novel methodology paves way for continued research into the molecular basis of this complex cycle as well as other regenerative organs like skin and liver.

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  • Pushing the Molecular Switches of Tuberculosis Into Overdrive

    Mycobacterium tuberculosis (MTB) infects more than 1.5 billion people worldwide partly due to its ability to sense and adapt to the broad range of hostile environments that exist within hosts.

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  • Let Us Tell You Everything We Know About Proteomics – Everything

    Proteomics experiments generate huge amounts of raw data, most of which cannot be easily shared or described in a publication.
    ISB researchers curate publicly accessible databases that allow researchers to share their data with the world and to use data others have collected.

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  • How One Family of Microbial Genes Rewires Itself for New Niches

    When an organism duplicates its genes, it increases its ability to adapt and colonize new environments.
    ISB researchers used the systems approach to study how one family of microbial genes evolved to bring functions that were adaptive to specific environments.

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  • What’s the Secret to ‘Extreme Longevity’?

    ISB researchers and their collaborators studied a group of supercentenarians (110 years or older) to explore the genetics of ‘extreme longevity.’
    The group performed whole-genome sequencing on 17 supercentenarians in order to look for any rare protein-altering variants associated with extreme longevity.

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  • How Physics and Thermodynamics Help Assess DNA Defects in Cancer

    ‘Big data’ cancer research has revealed a new spectrum of genetic mutations across tumors that need understanding.
    Existing methods for analyzing DNA defects in cancer are blind to how those mutations actually behave.

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  • A New Approach to Identifying How the Deadly Dengue Virus Multiplies

    Dengue virus is the most prevalent mosquito-borne virus worldwide, infecting an estimated 400 million people per year and causing about 25,000 deaths.
    It’s necessary to understand the molecular mechanisms of dengue replication in order to develop an effective treatment.

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  • New Details on Thyroid Cancer May Lead to More Precise Therapies

    Papillary thyroid cancer represents 80 percent of all thyroid cancer cases.
    Integrative analysis resulted in the detection of significant molecular alterations not previously reported in the disease.

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  • New Tool Uses 3-D Protein-DNA Structures to Predict Locations of Genetic ‘On-Off’ Switches

    Novel systems approach uses high-resolution structures of protein-DNA complexes to predict where transcription factors (genetic switches) bind and regulate the genome.
    This approach can help researchers better understand and predict binding sites for non-model organisms or ‘exotic’ species.

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  • Uncovering the Genetic Adaptability of Tuberculosis

    The Institute for Systems Biology and Seattle BioMed have collaborated to reconstruct the gene regulatory network of the human pathogen Mycobacterium tuberculosis.
    Finely tuned gene regulation has allowed Mycobacterium tuberculosis to survive unnoticed in an apparently healthy host for decades; understanding those subtleties is critical for advancing treatment.

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  • Analyzing Family Genomics Reveals New Culprit in Rare Disease

    Adams-Oliver syndrome (AOS) is a rare congenital disease characterized by scalp lesions and limb defects. Additional vascular abnormalities and heart defects can lead to early death in some patients.

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  • New Structural Map Helps To Understand Aggressive Tumors

    Aggressive tumor growth is linked to high activity of a macromolecular assembly called RNA polymerase I.
    ISB and FHCRC researchers collaborate to map the architecture of the assembly using a powerful crosslinking-mass spectrometry (CXMS) technology.

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  • ISB's Ilya Shmulevich describes his lab's work in The Cancer Genome Atlas project and how ISB and FHCRC could collaborate.

    BIOCELLION: New Supercomputer Software Framework Models Biological Systems at Unprecedented Scales

    Computer simulation is a promising way to model multicellular biological systems to help understand complexity underlying health and disease.
    Biocellion is a high-performance computing (HPC) framework that enables the simulation of billions of cells across multiple scales.

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  • Identifying Four New Subtypes of Gastric Cancer That May Lead to New Targeted Treatments

    Gastric cancer has a high mortality rate, but current classification systems haven’t been effective in helping to identify subtypes relevant for treatment of the disease.
    TCGA researchers have integrated molecular data from 295 stomach tumors and have discovered four subtypes of gastric cancer.

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  • New Open-Access Multiscale Model Captures Dynamic Molecular Processes in Unprecedented Detail

    Microbes are efficient because their streamlined genomes allow them to evolve and adapt rapidly to complex environmental changes.
    Decoding the highly-compressed information within a microbial genome requires sophisticated systems biology tools to map the genetic programs, and understand how they are executed.

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  • New Protein Modification Critical to Growth of Tuberculosis Pathogen Found

    Institute for Systems Biology and Seattle BioMed researchers collaborated and discovered a new protein post-translational modification in the human pathogen Mycobacterium tuberculosis.
    Post-translational modifications are essential mechanisms used by cells to diversify protein functions and ISB scientists identified the rare phosphorylated tyrosine post translational modification on Mycobacterium tuberculosis proteins using mass spectrometry.

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  • Now researchers can explore genomic data across space and time

    Understanding systems from a multiscale perspective gives us a more detailed and holistic view of how features or functions from each scale connect and interact in a given system.
    The challenge is integrating the different types of information that come from each scale in an efficient way that yields the most insight.

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  • The Rise of Open Proteomics

    Researchers at EMBL-EBI, Institute for Systems Biology and other partnering organizations have launched ProteomeXchange, a public portal for exchanging proteomics data generated from mass-spectrometry experiments and other related information.

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  • ‘Demystifying Disease, Democratizing Health Care’

    In Science Translational Medicine, Dr. Lee Hood and Dr.

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  • Unpredictable Environments Require Predictably Fast Responses

    ISB researchers discover a novel mechanism used by cells to rapidly turn “on” or “off” genes in order to change survival strategies in response to environmental events.
    The “switch” was discovered in Halobacterium salinarium and found to be conserved in diverse life forms.

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  • Tiniest Malfunctions in a Cell Can Cause Devastating Diseases

    ISB researchers are studying peroxisomes, which are cellular organelles that are linked to a rare syndrome that causes progressive organ complications and infant mortality.
    Peroxisomes have a role in metabolizing and breaking down cellular waste.

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  • Matters of the Head and the Heart

    Previous links between posttraumatic stress disorder (PTSD) and cardiovascular disorders were mostly thought to be psychological.
    Using mouse models, researchers at ISB and U.

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  • Powerful New Program Integrates Multiple Tools Into a Flexible Interface

    Price Lab researchers worked with collaborators at the University of Illinois to create an easy-to-use software toolkit for comparing microbial genomes.
    Tools can be used to find orthologs, correct missing/inaccurate gene annotations, analyze gene gain and loss patterns, and build draft metabolic networks from reference networks.

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  • 50 Years in the Lab Doesn’t Diminish an Organism’s Memory of Its Natural Environment

    ISB researchers discover that microbes retain complex survival traits despite having been domesticated for more than 50 years.
    Study reveals that gene networks store a historic record of environmental change.

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  • The Bug Stops Here: Arresting Malaria Parasites in the Liver Gives Immunity

    ISB researchers collaborated with Seattle BioMed researchers to identify molecular building blocks required by malaria parasites to build cell membranes.
    Deleting key genes necessary for building cell membranes created a parasite that does not make the host sick and can’t be passed on through the blood.

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  • Participatory Medicine is Revolutionizing Healthcare

    Dr. Lee Hood and his colleague Dr.

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  • ISB Researchers Develop New Method to Study and Predict Traits of Cells

    ISB researchers used the systems approach to develop a new way to integrate data from different classes of networks to better understand how cells function.
    The method is a software program called GEMINI and it’s the first of its kind to integrate data from metabolic networks to refine transcriptional regulatory networks.

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  • ISB’s PeptideAtlas Helps Advance the Study of Proteins

    The Human Proteome Project expands on the work of the Human Genome Project.
    ISB is a leader in proteomics and developed PeptideAtlas, a project that has cataloged the proteins observed in thousands of proteomics experiments as an open resource for researchers everywhere.

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  • A ‘Sound Check’ for Digital Transcriptomes

    Looking for biomarkers in different types of tissues requires comparing massive amounts of gene expression data.
    In order to compare ‘digital transcriptome’ data, they have to be normalized or adjusted to a common standard of measurement.

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  • How ISB’s Systems Approach Finds New Biological Insight from Existing Big-Data Sets

    There exist copious amounts of public research data that can reveal new biological information if they are integrated and analyzed.
    One of ISB’s specialties is the ability to apply systems approaches to develop methods to integrate and analyze data.

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  • Systems Approach to Innovation Helps Extract More Data

    Technology lag affects the study of proteins, which when quantified can indicate disease or wellness.
    ISB uses systems approach to innovate and transcend technology limitations.

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  • Blood Test Helps Identify Benign Lung Nodules

    When it comes to determining whether lung nodules are benign, a patient typically faces surgery and a biopsy. It’s an invasive and costly response, and, in 80 percent of cases, unnecessary.

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  • New Principle of Chemo-Resistance Sheds Light on Evasiveness of Cancer Cells

    Each year more than half a million people in the U.S.

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  • ISB Analysis May Lead to Earlier Diagnoses of Deadly Brain Tumor

    ISB researchers present a computational analysis of astrocytoma tumors — including the most aggressive form called glioblastoma multiforme or GBM — that could enable better tumor characterization and classification. Having these data may lead to earlier diagnoses, which are crucial to enable more effective therapy choices for battling these tumors.

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  • Largest Genetics Catalog of Deadliest Brain Tumor Released

    Glioblastoma multiforme (GBM) is the most common and deadliest of malignant primary brain tumors in adults. Because of its lethality, GBM was selected as the first brain tumor to be sequenced as part of The Cancer Genome Atlas (TCGA), a comprehensive project funded by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) to map the genomes of more than 25 types of cancer.

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  • New Predictive Model for Gene Regulation of Methanogenesis of M. maripaludis

    Methanogens catalyze the critical, methane-producing step (called methanogenesis) in the anaerobic decomposition of organic matter. Scientists at ISB and University of Washington led a multi-institutional effort to generate the first predictive model for gene regulation of methanogenesis in a hydrogenotrophic methanogen, Methanococcus maripaludis.

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  • Non-Darwinian Dynamics in Therapy-Induced Cancer Drug Resistance

    The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastable phenotypic variants (persisters), some of which represent stem-like states that confer resistance.

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  • Pan-Cancer Project

    The Cancer Genome Atlas research network has launched the Pan-Cancer project to analyze multiple tumor types together to find common events across different tumors. The availability of large cohorts and multiple different types of data at the DNA, RNA, and protein levels has made the Pan-Cancer project possible.

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  • Version 6 of Consensus Yeast Metabolic Network Released

    Updates to maintain a state-of-the art reconstruction of the yeast metabolic network are essential to reflect our understanding of yeast metabolism and functional organization, to eliminate any inaccuracies identified in earlier iterations, to improve predictive accuracy and to continue to expand into novel subsystems to extend the comprehensiveness of the model. Here, we present version 6 of the consensus yeast metabolic network (Yeast 6) as an update to the community effort to computationally reconstruct the genome-scale metabolic network of Saccharomyces cerevisiae S288c.

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  • Evaluating Effects of Variable Single-Cell Protein Expression on Metabolism

    Stochastic gene expression can lead to phenotypic differences among cells even in isogenic populations growing under macroscopically identical conditions. Here, we apply flux balance analysis in investigating the effects of single-cell proteomics data on the metabolic behavior of an in silico Escherichia coli population.

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  • New Open-Access Software Helps Predict Cellular Actions Tied to Diseases, Drug Targets

    All living things are made of cells that contain DNA, which help determine their physical characteristics. In addition to this encoded genetic information, organisms are also defined by the way they decode information from interactions with their environments.

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  • Some Algae Are Destined to Die for the Good of the Planet

    Nearly 25 gigatons of carbon is cycled annually through the oceans, replenishing resources for a healthy planet. This process is carried out by interactions among different groups of microorganisms, each performing a different role in a network that has come to be known as the microbial loop.

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  • Unlocking Molecular Signatures of Endometrial Cancer Subtypes

    Endometrial cancers affect many women in the United States. In 2012, 47,000 new cases and 8,000 deaths were estimated – making endometrial cancer the fourth most common type of cancer among US women.

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  • Discovery of Microbial Biological Clock May Shed Light on Ocean Health

    Oceans contain innumerable species of diatom microbes that are responsible for half of the Earth’s oxygen production, as well as CO2 removal, a critical exchange in the web of life. The current understanding of these single-celled organisms is limited.

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  • Biggest Family Tree of Human Cells May Help Develop Cell-Replacement Therapies

    Scientists at Institute for Systems Biology (ISB), University of Luxembourg, and Tampere University of Technology have created a method that identifies the genetic toggle switches that determine a cell’s developmental fate. This research, published on April 21 in the journal Nature Methods, may lead to new discoveries in disease treatments and tissue-regeneration technologies.

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  • Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

    NLRP3 is a key component of the macromolecular signaling complex called the inflammasome that promotes caspase 1-dependent production of IL-1β. The adaptor ASC is necessary for NLRP3-dependent inflammasome function, but it is not known whether ASC is a sufficient partner and whether inflammasome formation occurs in the cytosol or in association with mitochondria is controversial.

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  • Role of Key Nuclear Pore Proteins on the Assembly of Chromatin

    The three-dimensional architecture of a cell’s nucleus, which contains its genetic information, is critical to determining which of a cell’s genes are actually expressed. Using systems and cell biology techniques, researchers have identified how nuclear pore complexes—collections of proteins studding the nuclear membrane— serve as key elements in defining nuclear architecture and controlling which genes get expressed.

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  • A ‘Google Map’ of Human Metabolism

    ISB’s Nathan Price and Vangelis Simeonidis, a visiting scholar from Luxembourg Centre for Systems Biomedicine (LCSB is a major strategic partner with ISB), contributed to this paper – “A community-driven global reconstruction of human metabolism” – that was published today in Nature Biotechnology. An excerpt describing the collaborative project from a press release is below.

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  • Only at ISB: Our Proteomics Journey

    ISB was founded in 2000 by Dr. Lee Hood, a systems biologist; Dr.

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  • Revolutionizing medicine in the 21st century

    This paper, co-authored by Lee Hood, Rudi Balling and Charles Auffray, was published in Biotechnology Journal.

    “Revolutionizing medicine in the 21st century through systems approaches”

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