ISB News

Genome fingerprinting

Genome Comparison Easier with ‘Fingerprint’ Method

ISB researchers have developed a method of capturing a personal genome as a “fingerprint,” which will have a major impact on how quickly and efficiently genome sequences are compared.

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The Institute for Systems Biology has a mission to make data available to the world. In a paper recently published in the journal Current Protocols in Bioinformatics, proteomics researchers in the lab of Dr. Robert Moritz provide a step-by-step tutorial demonstrating how to take advantage of web-based applications that let researchers share and use proteomics data.

Let Us Tell You Everything We Know About Proteomics – Everything

3 Bullets: Proteomics experiments generate huge amounts of raw data, most of which cannot be easily shared or described in a publication. ISB researchers curate publicly accessible databases that allow researchers to share their data with the world and to use data others have collected. All data are analyzed in a consistent manner and results are presented via searchable, user-friendly web applications. By Dr. Kristian Swearingen Institute for Systems Biology…

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Lee Hood Receives IEEE Medal for Innovations in Healthcare Technology

Dr. Lee Hood received the IEEE Medal for Innovations in Healthcare Technology at a ceremony in Amsterdam on Aug. 23, 2014. Please watch a video of his acceptance speech here. IEEE Spectrum Magazine also published an article featuring an interview with Lee: “Medicine’s Next Big Mission: Understanding Wellness” Read article…

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NIH awards $10.9 million to National Center for Dynamic Interactome Research

New $10.9 Million Grant from NIH

The NIH's National Institute of General Medical Sciences has issued a Biotechnology Resource Grant of $10.9 million over five years to the National Center for Dynamic Interactome Research (ncdir.org) project. This project is a collaboration among The Rockefeller University, Institute for Systems Biology, Seattle BioMed, University of California at San Francisco, New York University and New York Structural Biology Center. Michael Rout, of The Rockefeller University, is the Program Director/Principal…

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Cover image for ISB's 2013 Annual Report.

ISB’s 2013 Annual Report is Now Available

Institute for Systems Biology has a dizzying breadth of research projects. But when we talk about what we do, it’s how we do it that matters most. The systems approach that we pioneered and exemplify continues to distinguish our ability to tackle the most complex biological and environmental challenges today. Because of how we apply our hallmark collaborative, cross-disciplinary and integrative approach, our collective success is greater than the sum…

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ISB and Seattle BioMed held its annual Lightning Talks on June 12, 2014. The talks offer scientists the chance to share current research and to enable potential collaborations across institutes.

3-Minute Science: ISB and Seattle BioMed Hold Annual Lightning Talks

Photo: Theo Knijnenburg, a research scientist in ISB's Shmulevich Lab, presentaed a summary of his work related to gene mutations and cancer drug sensitivity. Systems biology is about the culture as much as a scientific approach. ISB and Seattle BioMed have an inter-institutional agreement that enables the collective to benefit from shared knowledge and technology resources. For the second consecutive year, we held Lightning Talks (June 12) to allow researchers…

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Lee Hood Wins IEEE Innovations in Healthcare Technology Award

Lee Hood Wins IEEE Medal for Innovations in Healthcare Technology

IEEE (Institute of Electrical and Electronics Engineers) announced that Dr. Lee Hood, president of Institute for Systems Biology, is the 2014 recipient of the Medal for Innovations in Healthcare Technology. He is being recognized for "pioneering contributions to DNA sequencing technologies that revolutionized life and health sciences." Read about all the medal recipients here.  

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ISB Data Science/Data Visualizaiton Meetup

Data Vis Meetup Held at ISB

Pictured above: Allison Kudla presents ISB’s Big Data Science site at the start of the meetup. ISB hosted the Seattle Vis meetup group this past Wednesday (April 30). The meetup was organized by Noah Iliinsky and facilitated by ISB’s Dick Kreisberg. The guest speakers were Ryan Lucas and Kevin Lynagh, who have created a very stylistic charting library based on a grammar of graphics. They are an independent data vis…

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ISB hosted its annual Symposium on April 13-14, 2014.

ISB’s Annual Symposium

ISB held its 13th Annual International Symposium: Systems Biology & Cancers From Big Data to Personalized Treatment on April 13-14, 2014. Visit symposium.systemsbiology.net for details. Visit the gallery for images. Or visit the video playlist on ISB’s YouTube channel.

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Now researchers can explore genomic data across space and time

The figure above is part of a four-step procedure for the multiscale segmentation of genomic signals. 3 Bullets: Understanding systems from a multiscale perspective gives us a more detailed and holistic view of how features or functions from each scale connect and interact in a given system. The challenge is integrating the different types of information that come from each scale in an efficient way that yields the most insight….

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ISB’s Robert Moritz Lab Receives NIGMS Grant for Trans Proteomic Pipeline

The National Institute Of General Medical Sciences of the NIH has awarded Principal Investigator(s): Eric Deutsch, PhD, and Robert L. Moritz, PhD, a continuing R01 grant GM087221 for the ongoing development of the Trans-Proteomic Pipeline. The award titled “Development of Trans Proteomic Pipeline, an Analysis Suite for Mass Spectrometry” will continue the work of the ISB flagship proteomics analysis suite of open-source programs that has been downloaded thousands of times…

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ISB’s Trans Proteomic Pipeline Software in Demand

Luis Mendoza and Eric Deutsch, of the Moritz lab, were at CINVESTAV (a federal institute in Irapuato, Mexico) last week to teach a workshop on the Trans-Proteomic Pipeline software. From Luis (pictured above): "We covered the basics of data analysis of tandem mass spectrometry data using the TPP, including the justification and theory behind the methods as well as interpretation of the results via hands-on tutorials. We had a full…

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Profiles of Innovation: Lee Hood at Northeastern University

Our Lee Hood was the featured guest on Nov. 5 at Boston's Northeastern University for the Profiles in Innovation Presidential Speaker Series. You can read the accompanying news story here.

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ISB Co-Authored Nature Paper Featured in the New York Times

The Ilya Shmulevich Group at ISB has been participating in The Cancer Genome Atlas (TCGA) project as a Genome Data Analysis Center. The first paper resulting from the main phase of the TCGA project – "Comprehensive molecular characterization of human colon and rectal cancer" – was published in the July 19, 2012, issue of Nature and also featured on the front page of the New York Times. ISB teamed up…

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ISB Featured in Google I/O Conference Keynote

We were very excited to watch the live stream of the keynote from the Google I/O conference today, because it featured work from ISB's Shmulevich Lab, which is one of a group of research organizations that has been working on The Cancer Genome Atlas (TCGA). To help visualize the TCGA data, the lab created the Cancer Regulome Explorer using Google App Engine and Google Compute Engine. Google Compute Engine is…

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ISB Innovation in Action

Above: Kristian Swearingen and the re-engineered FAIMS device. (Editor's Note: This post shows a wonderful example of the collaborative, innovative and entrepreneurial ethic that ISB nurtures. Even if the science or technology is difficult to explain concisely, the cross-disciplinary and integrative nature of how our work is done and the pioneering spirit come through. How cool is that?) By Terry Farrah What do you do when your mass spectrometer accessory…

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Genome Ethics

By Chris Witwer The Health and Human Service human research regulations are being revised. Scientists' input on whole genome sequencing data may shape the future of research. It's great that the article below says that change is "imminent." Here's an article that describes the issue: DNA Mapped in a Day Prompts U.S. Review of Genome Ethics And here's a document from the Department of Health and Human Services: https://s3.amazonaws.com/public-inspection.federalregister.gov/2012-07329.pdf The…

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Medicine 2.0: A Digital You

Dr. Eric Topol was a guest on KUOW/NPR this morning to discuss his new book "The Creative Destruction of Medicine" which talks about how the digital revolution can dramatically change healthcare and the practice of medicine. When we talk about P4 Medicine, we encourage people to understand – and embrace – the technology that's already available and the promise of a future when doctors will know exact data about your…

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