ISB News

CRI, ISB, Sage Bionetworks Unveil Comprehensive Immunotherapy Tool

Three organizations on the forefront of cancer immunotherapy, systems biology and bioinformatics announced the release of the Cancer Research Institute iAtlas, a comprehensive web-based tool that allows oncologists and researchers to study and analyze interactions between tumors and the immune microenvironment.

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Genome fingerprinting

Genome Comparison Easier with ‘Fingerprint’ Method

ISB researchers have developed a method of capturing a personal genome as a “fingerprint,” which will have a major impact on how quickly and efficiently genome sequences are compared.

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A Landscape of Pharmacogenomic Interactions in Cancer

The journal Cell published a study today (July 7) about the integrated analysis of drug response in 1,001 cancer cell lines. This study was undertaken by a large international group of researchers including ISB Senior Research Scientist Theo Knijnenburg. The researchers integrated heterogeneous molecular data of 11,215 tumors and 1,001 cell lines in order to study the drug response of these cell lines to 265 anti-cancer drugs. They uncovered numerous…

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New Publication in ‘Cancer Cell’

As part of The Cancer Genome Atlas project, the Shmuelvich Lab and colleagues published a paper in the journal Cancer Cell related to the rare cancer adrenocortical carcinoma. Read the summary: 3 Bullets: Adrenocortical carcinoma (ACC) is a rare, under-researched endocrine cancer with limited therapeutic options and overall poor outcome. TCGA researchers performed comprehensive analysis of 91 ACC samples to gain better understanding of potential genetic causes of the cancer….

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Ilya Shmulevich at GCPNext

Using Google Cloud Platform to Give Researchers Easier Access to Cancer Data

ISB’s Dr. Ilya Shmulevich attended Google Cloud Platform’s GCPNext conference in San Francisco and presented on ISB’s Cancer Genomics Cloud project. He explains how his team used GCP to create better access for a broad range of researchers to cancer genomics data (from The Cancer Genomics Atlas) and the tools with which to explore that data. Watch Dr. Shmulevich’s talk below.

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ISB Launches 3-Year Wilke Lyme Disease Project with $2.13M Funding

Study Utilizes Systems Approaches to Develop Diagnostics and Deeper Understanding of Chronic Lyme PRESS RELEASE, SEATTLE, March 26, 2015 – Institute for Systems Biology (ISB) has received $2.13 million in transformational gifts from Jeff and Liesl Wilke; Jeff and MacKenzie Bezos; and the Bay Area Lyme Foundation to tackle chronic Lyme disease, a highly complex and often misdiagnosed disease that can be debilitating for those who do not respond to…

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Into the genetic weeds of hair growth

3 Bullets: ISB researchers used a data-driven mathematical model to identify specific genes associated with hair regeneration Novel methodology paves way for continued research into the molecular basis of this complex cycle as well as other regenerative organs like skin and liver Findings may lead to more precise targets for therapies and genetic markers of hair wellness By Varsha Dhankani Scientists at ISB have identified genes associated with the growth-and-death…

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ISB Recieves $6.5M NIH Contract to Create Cancer Genomics Cloud with Google and SRA International (Image credit: MIT Tech Review)

Cancer Genomics Cloud: ISB and Google Featured in MIT Tech Review

(Above illustration from MIT Technology Review.) MIT Technology Review published an article about the launch of Google Genomics and included a mention of ISB’s new Cancer Genomics Cloud project. ISB received an up-to $6.5 million, two-year NIH contract in collaboration with Google and SRA International. From the MIT Technology Review article: The idea is to create “cancer genome clouds” where scientists can share information and quickly run virtual experiments as…

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How Physics and Thermodynamics Help Assess DNA Defects in Cancer

3 Bullets: ‘Big data’ cancer research has revealed a new spectrum of genetic mutations across tumors that need understanding. Existing methods for analyzing DNA defects in cancer are blind to how those mutations actually behave. ISB scientists developed a new approach using physics- and structure-based modeling to systematically assess the spectrum of mutations that arise in several gene regulatory proteins in cancer. By Jake Valenzuela and Justin Ashworth A significant…

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Cancer genomics visualization at ISB

It’s Easier to Go ‘Viral’ When Your Partner Happens to be Google

By ISBUSA Since we announced that we got a $6.5 million contract from NCI to develop the Cancer Genomics Cloud pilot project, we’ve gotten some great press from around the world. It doesn’t hurt that one of our partners is Google, of course. Here are some of the headlines from around the world: Puget Sound Business Journal: Cancer in the cloud: Institute for Systems Biology teams up with Google NBCNews.com:…

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Analyzing Family Genomics Reveals New Culprit in Rare Disease

3 Bullets: Adams-Oliver syndrome (AOS) is a rare congenital disease characterized by scalp lesions and limb defects. Additional vascular abnormalities and heart defects can lead to early death in some patients. By analyzing twelve families affected with the disease, we identified causal mutations in a new disease gene, NOTCH1, in five families. NOTCH1 is likely to be the major cause of AOS. NOTCH1 codes for a transcription factor that governs…

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A Personal Love

ISB Senior Researcher Shares Ode to DNA By Jared Roach, MD, PhD Here is my personal ode to DNA. Valentine’s day is coming and this ode is overdue. For those of you attending my talk on personal genome sequencing tonight (Monday, February 11) at 7 p.m. at Wilde Rover in Kirkland, I have put in some links to books that I think you might really enjoying reading. What does the…

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A Personal Love: ISB Senior Scientist Shares Ode to DNA

By Jared Roach, MD, PhD Here is my personal ode to DNA. Valentine’s day is coming and this ode is overdue. For those of you attending my talk on personal genome sequencing tonight (Monday, February 11) at 7 p.m. at Wilde Rover in Kirkland, I have put in some links to books that I think you might really enjoying reading. What does the genome mean to me personally? How is…

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ISB at Eastside Science Cafe

Personal Genome Sequencing Discussion at Eastside Science Cafe. Jared Roach, Ph.D., M.D., Institute for Systems Biology, will be presenting at Eastside Science Cafe: Monday, 11 February 2013 – 7:00pm Location: Wilde Rover, Kirkland Click here for Map The first personal genomes were sequenced only five years ago and cost millions of dollars. Personal genome sequencing is now a thousand times cheaper, and many people are considering sequencing their own genomes…

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Watch Cracking Your Genetic Code on PBS. See more from NOVA.

Lee Hood Talks Actionable Genes in NOVA’s ‘Cracking Your Genetic Code’

If you missed the NOVA special "Cracking Your Genetic Code" you can watch it here. Our president, Lee Hood, was among the experts featured in the documentary.

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Genome Ethics

By Chris Witwer The Health and Human Service human research regulations are being revised. Scientists' input on whole genome sequencing data may shape the future of research. It's great that the article below says that change is "imminent." Here's an article that describes the issue: DNA Mapped in a Day Prompts U.S. Review of Genome Ethics And here's a document from the Department of Health and Human Services: https://s3.amazonaws.com/public-inspection.federalregister.gov/2012-07329.pdf The…

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Watch Cracking Your Genetic Code Preview on PBS. See more from NOVA.

Lee Hood on NOVA on March 28

We are eager to watch the NOVA documentary tonight on PBS called "Cracking Your Genetic Code." Lee Hood is one of the featured experts. The producer, Sarah Holt, began with a series of phone interviews late last summer before interviewing Lee on camera in her Boston studio. Here's a preview radio segment on the Emily Rooney Show that features Holt and Dr. Rudy Tanzi, who also appears in the documentary….

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Our Genomes, Our Selves: The hunt for a disease gene

By Lee Rowen Every once in a while, different components of a research problem come together at just the right time. One lives for, and savors, these occasions. One of my favorite examples is the discovery of the genetic variant that causes hereditary pancreatitis. Hereditary pancreatitis (HP) causes painful attacks of the gut, often beginning in childhood. Over time, the pain and damage can become chronic and there is an…

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