ISB Researchers Demonstrate Computational Method for the Maximizing Biological Information from Genetic Interaction Data

April 13, 2009

SEATTLE, April 13, 2009 – Researchers at the Institute for Systems Biology (ISB) have demonstrated a new computational method for getting the most biological information out of huge and growing sets of genetic interaction data. A paper addressing the development has been published in the April edition of PLoS Computational Biology at

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Systems Biology Provides First Global Analysis of Prion Disease in a Mouse Model

March 24, 2009

SEATTLE, March 24, 2009 – Researchers at the Institute for Systems Biology (ISB) in Seattle and the McLaughlin Research Institute in Great Falls, Montana, published today in Molecular Systems Biology a ground-breaking study which modeled the progression of degenerative brain diseases, one of which is "mad cow disease," that are caused by misfolded proteins called "prions". The paper can be accessed at

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ISB Researchers Develop Fully Automated, High Throughput Microfluidic Experiment Platform

February 18, 2009

SEATTLE, February 18, 2009 – Researchers at the Institute for Systems Biology in Seattle and the University of British Columbia have develop a new fully automated microfluidic experiment platform for conducting live-cell experimentation that enables high throughput imaging and on-chip microenvironment manipulation.

A paper describing the platform was published recently in the Proceedings of the National Academy of Sciences.

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Swedish Neuroscience Institute and Institute for Systems Biology Form Alliance to Learn More about Brain Diseases

September 30, 2008

SEATTLE, Sept. 30, 2008 – The Swedish Neuroscience Institute (SNI) has joined forces with the Institute for Systems Biology (ISB) to fundraise for and collaborate on research they hope will lead to cures for diseases of the brain and nervous system. The new partnership brings together physicians, researchers and fundraisers from two of the most respected organizations in the Pacific Northwest.

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Model Developed that Predicts Molecular Response of Living Cells to Genetic or Environmental Change

December 27, 2007

SEATTLE, WA – December 27, 2007 – Scientists at the Institute for Systems Biology (ISB), in collaboration with researchers from New York University (NYU), have developed a model which rapidly characterizes and accurately predicts the molecular-level, mechanistic response of a free-living cell to genetic and environmental changes. The paper describing the EGRIN model was published today in the online edition of the journal Cell.

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Bill Gates and Nathan Myhrvold to Keynote Institute for Systems Biology´s 2008 Annual Symposium

November 5, 2007

SEATTLE, WA – November 5, 2007 – The Institute for Systems Biology announces that Bill Gates, co-chair of the Bill & Melinda Gates Foundation and chairman of Microsoft Corporation and Nathan Myhrvold, PhD, president and CEO of Intellectual Ventures, will serve as keynote speakers for the 7th Annual Institute for Systems Biology International Symposium.

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Leroy Hood Achieves Scientific Grand Slam

September 25, 2007

SEATTLE, WA – September 25, 2007 – Leroy Hood, M.D., Ph. D, president of the Institute for Systems Biology, is being inducted into the National Academy of Engineering on Sept. 30 in Washington D.C., making him one of only seven individuals currently elected to three National Academies—the National Academy of Engineering, the National Academy of Science and the Institute of Medicine of the National Academies.

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The Institute for Systems Biology Receives a $721,000 K-12 Science Education Grant from the Howard Hughes Medical Institute

June 21, 2007

SEATTLE -- June 21, 2007 -- The Institute for Systems Biology (ISB) has received a five-year, $721,000 grant from the Howard Hughes Medical Institute. The Center for Inquiry Science (CIS) at ISB will use the grant to collaborate with the Renton Schools in training the district's K-5 professional development staff in the systems approach to science. CIS is the education arm of the non-profit ISB.

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Researchers Announce Model for Predicting Outcomes of Multi-gene Interactions

March 27, 2007

SEATTLE -- March 27, 2007 -- Researchers at the Institute for Systems Biology (ISB) have developed new techniques to predict how mutating gene combinations impact the ability of yeast cells to respond to environmental stress. The research, published today in Molecular Systems Biology, could lead to advances in the understanding and treatment of human disease, because most illnesses result from the interaction of multiple genes rather than the action or mutation of a single gene.

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