ISB News

ISB's Dr. Sean Gibbons on the importance of the human microbiome

“This new organ that we’re coming to recognize as the microbiome is part and parcel to the functionality of the whole system, and if it breaks down, if it starts to fall apart, we start to get sick,” said Dr. Sean Gibbons, ISB’s newest faculty member, in a WGBH Forum Network presentation.

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ISB develops stress test to predict how diatoms will react to ocean acidification

In study published in Nature Communications and with implications for understanding effects of climate change, ISB researchers show microscopic phytoplankton are more resilient in an acidified environment.

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Dr. Sean Gibbons joins ISB faculty as WRF Distinguished Investigator

Dr. Sean Gibbons has joined ISB our newest faculty member. Gibbons’ new position brings a number of changes, including relocating to the Pacific Northwest from the Northeast. Read on for a Q&A with Gibbons that sheds light on his research career to date, areas of study and even a hidden talent.

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The Future of Health: Presentations from ISB’s 17th Annual International Symposium

At our 17th Annual International Symposium, focusing on the Future of Health, we welcomed speakers who are experts in diverse areas including environmental and occupational health, infectious disease transmission and forecast, drug and vaccine development, communicable disease dynamics, and beyond. Here is a video roundup of presentations from our two-day event.

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ISB’s Dr. Eliza Peterson Earns TB Junior Investigator Award

Dr. Eliza Peterson, a senior research scientist who studies tuberculosis (TB) in the Institute for Systems Biology’s Baliga Lab, has been recognized by the University of Washington’s Tuberculosis Research and Training Center with a TB Junior Investigator Award.

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Turn Health Care Right-Side Up: Focus On Wellness Not Disease

“Another vision for health care is emerging — one that is focused on wellness rather than disease; one that is proactive instead of reactive; one that takes a systems approach to biology and medicine rather than studying one gene, one cell or one protein at a time.” Read this Psychology Today story penned by ISB’s Lee Hood and Nathan Price.

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Image courtesy Circulation Research

Taking Systems Medicine to Heart

“Excessive spending and poor outcomes in health care and drug development necessitate the search for new research paradigms to translate cutting-edge, scientific discoveries of systems medicine into the clinic more quickly and efficiently.” ISB’s Kalliopi Trachana and colleagues, wrote “Taking Systems Medicine to Heart,” which was published in Circulation Research.

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2018 Consilience Event

ISB’s 2018 Consilience event on the topic of “Exploring Plasticity” will be held on Friday afternoon, May 25th. Speakers featured: Chris Young, CEO of ChefSteps and Michael Merzenich, PhD, CEO of BrainHQ.

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ISB’s Computational Teams Play Central Role in Completion of TCGA’s PanCancer Atlas Initiative

ISB’s computational and bioinformatics teams played a central role in the completion of the PanCancer Atlas Initiative, the final phase of TCGA. The culmination of this work is being published in 27 papers this week across the Cell Press research journals, including “The Immune Landscape of Cancer” in Immunity.

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CRI, ISB, Sage Bionetworks Unveil Comprehensive Immunotherapy Tool

Three organizations on the forefront of cancer immunotherapy, systems biology and bioinformatics announced the release of the Cancer Research Institute iAtlas, a comprehensive web-based tool that allows oncologists and researchers to study and analyze interactions between tumors and the immune microenvironment.

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Dr. John Aitchison Taps Systems Biology, Collaboration to Attack Infectious Diseases

John Aitchison is a pioneer in the field of systems biology. He is a founding member of Institute for Systems Biology (ISB), he was the long-time director of the Center for Systems Biology, and now he serves as president and director of Center for Infectious Disease Research (CIDR).

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Dr. Jim Heath Takes Helm of ISB, Looks Toward the Future

Jim Heath took over as president of Institute for Systems Biology on January 1. To fully appreciate Heath’s relationship with ISB, you have to go back to its early days – shortly after the research organization was founded in 2000.

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Key Strategies for Implementing Proteomics-Based Tests Across Disease States Highlighted in Current Opinion in Biotechnology

ISB, Integrated Diagnostics and Sera Prognostics just announced a paper entitled, “The building blocks of successful translation of proteomics to the clinic,” by Leroy Hood and colleagues published online in Current Opinion in Biotechnology.

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Clinical Trial Explores the Effects of Health Coaching on Cognitive Function in Patients with Early-Stage Alzheimer’s

Institute for Systems Biology (ISB) is among several organizations conducting a clinical trial testing how health coaching affects the cognitive function of patients with early-stage Alzheimer’s disease and analyzing longitudinal, multi-omic data to explore transitions in cognitive function over time.

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‘Fantastic Opportunity:’ ISB’s Scholars Program Offers Transformational Experience for Ambitious College Grads

ISB’s Systems Research Scholars Program (SRSP) is a two-year, fully funded training program for recent college graduates, and is designed to help transform exceptionally talented and ambitions post-baccalaureate students into the next generation’s pioneers of interdisciplinary research.

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High School Scientist Targets Sepsis, Earns $25,000 Scholarship Along the Way

Sriharshita Musunuri, 17, is looking to find and stop what causes sepsis, the top killer in American hospitals. She is collaborating with several ISB staff members, including mentor Chris Lausted, and just earned a $25,000 scholarship for her work.

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Lessons I Learned from My 17 Years as ISB President

Lee Hood co-founded Institute for Systems Biology in 2000, and has served as president of the institution since; on January 1, 2018, he left that role to serve as chief science officer of Providence St. Joseph Health. Here, Hood shares the many lessons he learned from 17 years at the helm of ISB.

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Dr. Sui Huang

New Principle for Eradicating Cancer: Leave No Dead Cells Behind

Dead cells, or cell debris, generated by treatments intended to eradicate tumor cells actually act as strong stimulators of tumor progression. The findings of ISB cancer biologist Sui Huang, his former mentee and longtime collaborator Dipak Panigrahy at Beth Isreal Deaconess Medical Center in Boston, and colleagues at Harvard Medical School were published in The Journal of Experimental Medicine.

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