April 2015

14th Annual International Symposium: Tipping Points in Medicine & Ecology
Monday, April 6, 2015 to Tuesday, April 7, 2015

14th Annual International Symposium
Institute for Systems Biology

The Institute for Systems Biology's Annual International Symposium, since its inception in 2002, has become a bellwether of new systems approaches across disciplines in the life sciences. The theme for 2015 is "Tipping Points in Medicine & Ecology" which is aligned with ISB's focus on personalized medicine and environmental sustainability. The principles of critical phase transitions, early warning signs and, more generally, complex systems dynamics, offer a theoretical framework and analysis tools for understanding and predicting major state transitions in human health and in ecosystems. The Symposium aims to facilitate the translation of these theoretical principles to medicine and ecology. We hope you will join us for a lively exchange of ideas.



November 2014

3rd Annual Valerie Logan Luncheon
Tuesday, November 18, 2014
Noon - 1:30 pm
ISB Main Floor

Inspiring Teachers to Inspire Students:
Next Generation Science

ISB and its Logan Center for Education are proud to present the 3rd Annual Valerie Logan Luncheon. On November 18, you will see how ISB’s Logan Center promotes Next Generation Science. The Center’s work empowers teachers to motivate students to ask questions, define problems and design solutions. These experiences cultivate students into science-literate citizens with the capacity to address our world’s problems both large and small. We will honor the 2014 recipient of the Valerie Logan Leadership in Science Education Award. We hope you will be inspired to make a contribution of $200, which will directly benefit ISB’s Logan Center for Education.

Visit the event site


Platinum Level Sponsor:

Muckleshoot Charity Fund


Gold Level Sponsors:

The Boeing Company


Aron M. Thompson





Integrated Diagnostics


July 2014

Monday, July 28, 2014 to Friday, August 1, 2014
9am to 5pm
ISB, 106

The goal of this course is to introduce the core concepts of systems biology and their application to systems biomedicine. We will demonstrate the importance of cross-disciplinary interactions for the success of systems biology programs.

Presented by the Institute for Systems Biology and the Center for Systems Biology.

To learn more and register for the course, click here!


May 2014

Single Cell Genomics on the C1 Instrument: Seminar
Friday, May 23, 2014
10 am - 1 pm
ISB, 106C

Fluidigm and ISB Present: A Seminar on Single Cell Genomics on the C1 Instrument.

Targeted gene expression, whole transcriptome analysis, DNA Sequencing and more.


Manisha Ray, Ph.D. -­‐ Applications Scientist, Fluidigm
Bryan Bell, Ph.D. -­‐ Regional Sales Manager, Clontech Laboratories

Peter Linsley, Ph.D. -­‐ Research Associate, Benaroya Research Institute “Single Cell Transcriptome of Antigen-­‐Specific T Cells”

Qiang Tian, Ph.D. – Senior Research Scientist, Institute for Systems Biology "Dissecting Brain Tumor Heterogeneity at Single Cell Resolution"

Please RSVP by Tuseday, May 20.



ISB GiveBIG May 6, 2014

ISB is a cutting-edge non-profit that needs your help to change the future of human health and the environment. GiveBIG on Tuesday, May 6!

Tuesday, May 6, 2014
12:00 am to 11:59 pm
The Seattle Foundation website

ISB's GiveBIG profile page

GiveBIG is an annual, community-wide day of giving hosted by The Seattle Foundation that aims to inspire regional philanthropy. Between midnight and midnight (PST) on May 6th, The Seattle Foundation and its generous sponsors will match a percentage of all contributions to local nonprofits.

If you are considering a gift to ISB in 2014, the GiveBIG campaign will be an opportunity to further the impact of your investment in the future of human health.

To learn more, click here.

April 2014

Symposium 2014: Systems Biology & Cancers

Symposium 2014: Systems Biology & Cancers: Big Data to Personalized Treatment

Sunday, April 13, 2014 to Monday, April 14, 2014
Institute for Systems Biology

Join a distinguished group of researchers and experts in Seattle for Institute for Systems Biology’s (ISB) 13th Annual Symposium, a two-day dialogue about cancers and how using a systems approach can help decipher some of its complexities. The Symposium will take place on April 13-14, 2014, at ISB’s state-of-the-art facilities in the South Lake Union neighborhood of Seattle. We welcome all who are interested in hearing from cancer researchers from institutions such as Oregon Health and Science University, Fred Hutchinson Cancer Research Center, University of Washington, Stanford, Memorial Sloan-Kettering Cancer Center, University of California, Santa Cruz, Institute for Systems Biology, Washington University School of Medicine in St. Louis, The University of Texas MD Anderson Cancer Center and more.

Visit the Site

Register Now

March 2014

Seattle Proteome Center
Monday, March 31, 2014 to Friday, April 4, 2014
9:00 am to 5:00 pm
First Floor, ISB

Proteomics Informatics Course at ISB: March 31 - April 4, 2014

Course Objective
The SPC is pleased to offer a five-day intensive in the use of a suite of open-source software tools designed for the analysis, validation, storage and interpretation of data obtained from large-scale quantitative proteomics experiments using stable isotope labeling method, multi-dimensional chromatography and tandem mass spectrometry.  Through daily lectures and tutorials, each course participant should become proficient in the use of the tools.

Learn More


Thursday, March 27, 2014
7:30 p.m.
Town Hall Seattle (downstairs)

Explore the cross-disciplinary and collaborative approach of systems biology and how it’s applied to cancer research. The Institute for Systems Biology combines innovative technologies, biological studies, and cutting-edge analysis to advance the field of cancer research. Panelists include Dr. Leroy Hood, President and Co-Founder of the Institute for Systems Biology; Dr. Anthony Blau, Professor in the University of Washington’s Division of Hematology, Department of Medicine and Adjunct Professor in the Department of Genome Sciences; Dr. Peter Nelson, prostate cancer researcher and oncologist at Fred Hutchinson Cancer Research Center; and other area experts in the field. Learn about the impact systems biology has on medicine, individual patients, and the community at large in this moderated forum. According to ISB, “we have a responsibility to share what we learn,” and this panel aims to do just that — share ISB’s groundbreaking research and what it means on an individual patient level. The panel is moderated by Dr. Eric Holland, Senior VP and Director of the Human Biology Division at Fred Hutchinson Cancer Research Center.

Presented by: Town Hall and the Institute for Systems Biology through The Seattle Science Lectures sponsored by Microsoft. Series media sponsorship provided by KPLU.
Tickets: $5.
Doors open: 6:30 p.m.
Town Hall member benefits: Priority seating.

Buy Tickets

Town Hall Seattle website


November 2013

Wednesday, November 13, 2013
Noon to 1:30 pm
ISB, Main Floor, 401 Terry Ave N. Seattle, WA 98109

Continuing Valerie’s vision...
Inspiring Teachers to Inspire Students:
Partnerships Between
Educators and
STEM Professionals
ISB is proud to present the 2nd Annual Valerie Logan Luncheon to celebrate Valerie’s vision for science education, and honor the 2013 recipient of the Valerie Logan Leadership in Science Education Award. We invite you to join our community of friends, supporters and partners for the luncheon. We hope you will be inspired to make a contribution of $200, which will directly benefit the education programs at ISB. You will ensure that engaged and enthusiastic teachers continue to open new worlds for all students.

Visit the event site


Thank you to our Gold Level Sponsors:






October 2013

Thursday, October 24, 2013
10.30 am - 11:30 am
106C, First Floor, ISB

Peter Turnbaugh, PhD

Bauer Fellow, FAS Center for Systems Biology at Harvard University, will be speaking at ISB on the topic:

Xenobiotic metabolism and resistance in the human gut microbiome

Our gastrointestinal tracts harbor complex microbial communities (the gut microbiota/microbiome) that encode a vast array of enzymatic activities, contributing to the metabolism of our diet and the drugs we take. Research over the past decade has emphasized that microbes are a key factor that shapes our health and predisposition to disease. Yet the molecular mechanisms responsible often remain unknown, making it challenging to translate these findings to new therapies and diagnostics, or to appreciate the broader biological, ecological, and evolutionary implications. As a tractable first step, my lab is focused on the microbial metabolism of and resistance to xenobiotics, including host-targeted drugs, antibiotics, and diet-derived bioactive compounds. These compounds are notable for their diverse chemical structures and effects on human and rodent physiology. Gut microbes are known to influence the efficacy and toxicity of >40 drugs through both direct and indirect interactions. We plan to use a combination of metagenomic sequencing, flow cytometry, and gnotobiotic mice (with defined or absent microbiomes). Our major goals are to: (i) elucidate the bacterial taxa and metabolic pathways involved in xenobiotic metabolism; (ii) determine how microbial communities adapt during exposure to xenobiotics; and (iii) test the relative importance of host, microbial, and environmental factors in shaping the bioavailability, efficacy, and toxicity of xenobiotics. Ultimately, we aim to obtain a more comprehensive view of human metabolism, yielding fundamental insights into host-microbial interactions, and supporting translational efforts to predict and manipulate the metabolic activities of our resident gut microbes.


PJT is supported by NIH-P50-GM068763.


Keywords: human microbiome, metagenomics, pharmacology, nutrition