Strategic Plan

Our Mission

Revolutionize science with a powerful systems approach to predict and prevent disease, and enable a sustainable environment.

 

Our Strategy

Develop a systems approach to characterize, predict, and manipulate state transitions in biological systems. By studying similar phenomena across diverse biological systems – from microbes to humans – we will leverage varying expertise, ideas, resources and opportunities to develop a unified systems biology framework.

Biological systems exist in a quasi-stable state that can evolve and adapt to environmental change, yet they are sufficiently robust to withstand stressful conditions and antagonistic interactions. Critical transitions across states and tipping points lay at the heart of most complex problems in modern biology, including reversible physiological adaptation to environmental change, evolution of interactions in the microbial loop, development of an adult body plan from an embryo, differentiation of a stem cell, and transition from health to disease. Characterizing warning signals before a tipping point is encountered is essential to develop early presymptomatic diagnostics for complex diseases. Finding the causal molecular mechanisms responsible for such transitions in turn will provide the strategies for prevention, intervention and reversal of disease. These concepts of diagnosis and intervention are also relevant for environmental issues as they will provide tools for better ecosystem monitoring, remediation and sustainable biotechnological solutions.

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Partnering with ISB

ISB has a long history of establishing strategic partnerships to tackle big challenges.

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