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Yong Zhou

At ISB, Dr Zhou is pioneering the use of novel systems biology techniques such as label-free quantitative proteomics and targeted Selective Reactive Monitoring (SRM) to facilitate biomedical researches. The main applications and research fields include: 1) discovery of novel biomarkers in body fluids (e.g.: blood, cerebrospinal fluid, and urine) for early stage disease detection and prognosis improvement, especially of cancers, neurodegenerative diseases, brain injury, and mental disorders; 2) discovery of novel pathogenesis mechanisms of diseases by investigating functions and effects of protein post-translational modifications in disease development and prognosis–for example, protein phosphorylation and glycosylation under hypoxia conditions in breast cancer cells; 3) optimization of biological sample preparation for mass spectrometry-based proteomics, including novel techniques to enrich tissue-derived, ultra low abundant proteins from body fluids, solid-phase extraction of glycosylated peptides from glycoproteins, and multiple methods of phosphopeptide enrichment.