Visualization of omics data for systems biology

TitleVisualization of omics data for systems biology
Publication TypeJournal Article
Year of Publication2010
AuthorsGehlenborg N, O'Donoghue SI, Baliga NS, Goesmann A, Hibbs MA, Kitano H, Kohlbacher O, Neuweger H, Schneider R, Tenenbaum D, Gavin AC
JournalNat Methods
Date PublishedMar
Keywords*Genomics, *Image Processing, Computer-Assisted, *Metabolomics, *Proteomics, *Systems Biology, Mass Spectrometry, Nuclear Magnetic Resonance, Biomolecular, Protein Binding
AbstractHigh-throughput studies of biological systems are rapidly accumulating a wealth of 'omics'-scale data. Visualization is a key aspect of both the analysis and understanding of these data, and users now have many visualization methods and tools to choose from. The challenge is to create clear, meaningful and integrated visualizations that give biological insight, without being overwhelmed by the intrinsic complexity of the data. In this review, we discuss how visualization tools are being used to help interpret protein interaction, gene expression and metabolic profile data, and we highlight emerging new directions.