Institute for Systems Biology 4th International Symposium Computational Challenges in Systems Biology **** 2005 International Symposium is Sold Out **** If you have any questions please contact Shawn Swift or 206-732-1232. The Institute for Systems Biology (ISB) will hold its fourth annual international symposium on Sunday, April 24th and Monday, April 25th at the ISB research facility in Seattle, Washington. This year's event, Computational Challenges in Systems Biology, will bring together world leaders in computational biology. Systems biology requires the integration of multiple disciplines including biology, technology, computation and medicine; all of which are evolving at exponential rates. This enormous rate of change poses new computational challenges on an unprecedented scale. But these are only the beginning: understanding the dynamic behavior of evolved systems demands new paradigms in model analysis and data visualization. How can we abstract from a system of thousands of interacting molecular species the underlying operational principles? Analogous to engineering design principles, we need to understand the functional and dynamic organizational principles of biomolecular networks. But, given the natural variability within cells over time, between cells within a tissue, and between individuals, how can we distinguish cause from effect, and essential from background/context? These and other computational challenges in systems biology will be addressed at the symposium. The event will begin on the afternoon of Sunday, April 24th with a keynote address from Nathan Myhrvold, Ph.D., Founder of Intellectual Ventures, LLC.

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