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Dr. Turkarslan is interested in understanding how cells respond to changes in the environment by reprogramming their gene regulatory networks (GRN) and delineating the principles underlying the evolution of these complex regulatory programs. He uses systems approaches in a model halophilic Archaea, Halobacterium salinarum, to understand how expansion of transcription factor families lead to GRN rewiring and enable cells to adapt into new environments. Specifically, he is developing a framework for tracking evolution of General Transcription Factor family by integrating environmentally relevant sub-functionalizations of each family member together with expression profiles, protein-DNA and protein-protein interaction data. In addition, he is also interested in Computational Biology, Genomics and Metagenomics.
Brooks, A.N., Turkarslan, S., Beer, K.D., Yin Lo, F., and Baliga, N.S. (2010) Adaptation of cells to new environments. Wiley Interdiscip Rev Syst Biol Med. [Epub ahead of print] PMID: 21197660
Sanders, C., Turkarslan, S., Lee, D.W., and Daldal, F. (2010) Cytochrome c biogenesis: the Ccm system. Trends Microbiol. 18:266-74. PMID: 20382024
Turkarslan, S., Sanders, C., Ekici, S., and Daldal, F. (2008) Compensatory thio-redox interactions between DsbA, CcdA and CcmG unveil the apocytochrome c holdase role of CcmG during cytochrome c maturation. Mol Microbiol. 70:652-66. PMID: 18786143
Sanders, C., Turkarslan, S., Lee, D.W., Onder, O., Kranz, R.G., and Daldal, F. (2008) The cytochrome c maturation components CcmF, CcmH, and CcmI form a membrane-integral multisubunit heme ligation complex. J Biol Chem. 283:29715-22. PMID: 18753134
Sanders, C., Turkarslan, S., Onder, O., Frawley, E.R., Kranz, R.G., Koch, H.G., and Daldal, F. (2008) Biogenesis of c-type Cytochromes and Cytochrome Complexes in The Purple Photosynthetic Bacteria. (Hunter, C.N., Daldal, F., and Thurnauer, M.C., editors), Springer.