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I am a biochemist, focused on impacting disease with the tools of proteomic- and combinatorial-chemistry.
As a postdoc at the ISB I have worked with a team of researchers using a targeted mass spectrometry-based approach to identify novel biomarkers of prostate cancer. My research goal in the near-term is to validate these proteomic findings and to characterize the mechanistic role of novel proteins as potential therapeutic targets. Over the long-term, I hope to impact cancer treatment through the development of new therapeutic reagents to interdict currently undruggable targets in the cell.
Austin R.J., Ja W.W., and Roberts R.W. (2008) Evolution of class-specific peptides targeting a hot spot of the Gas subunit. J. Mol. Biol. 377(5): 1406. PMID: 18329041, PMCID: PMC2891084.
Millward S.W., Fiacco S., Austin R.J., and Roberts R.W. (2007) Design of cyclic peptides that bind protein surfaces with antibody-like affinity. ACS Chem. Biol. 2(9): 625. PMID: 17894440.
Ja W.W., Wiser O., Austin R.J., Jan L.Y., and Roberts R.W. (2006) Turning G proteins on and off using peptide ligands. ACS Chem. Biol. 1: 570. PMID: 17168552, PMCID: PMC2802464.
Ja WW, Adhikari A, Austin RJ, Sprang SR, Roberts RW. (2005) A peptide core motif for binding to heterotrimeric G protein alpha subunits. J. Biol. Chem. 280: 32057. PMID 16051611,
Austin R.J., Xia T.B., Ren J.S., Takahashi T.T., and Roberts R.W. (2003) Differential modes of recognition in N peptide-boxB complexes. Biochemistry, 42(50): 14957. PMID: 14674772,
Austin R.J., Xia T.B., Takahashi T.T., and Roberts, R.W. (2002) Designed arginine rich RNA binding peptides with picomolar affinity. J. Am. Chem. Soc., 124(37): 10966. PMID: 12224929.