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Wednesday, November 18th |
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| 12:30 |
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Shuttle from the Sheraton Hotel to ISB |
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| 1:00 |
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Registration |
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| 1:45 |
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John Aitchison |
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Opening Remarks |
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| 2:00 |
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Session: Peroxisomal Disorders - John Aitchison (chair) |
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| 2:00 - 2:25 |
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Nancy Braverman |
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Recovery of Pex1-Gly834Asp peroxisome dysfunction by small molecule compounds |
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| 2:25 - 2:55 |
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Ann Moser |
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Newborn screening for X-linked Adrenoleukodystrophy (X-ALD): A combined liquid chromatography-tandem mass spectrometric (LC-MS/MS) method |
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| 2:40 - 2:55 |
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Hendrik Rosewich |
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Rational diagnostic strategy for peroxisomal biogenesis defects |
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| 2:55 - 3:10 |
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Werner Kovacs |
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Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress |
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| 3:10 - 3:30 |
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Q & A / Group discussion / Break |
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| 3:30 - 3:45 |
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Florian Eichler |
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Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy? |
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| 3:45 - 4:00 |
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Joseph Hacia |
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Evaluation of nonsense suppressor therapies in cells from patients with peroxisome biogenesis disorders |
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| 4:00 - 4:15 |
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Manuel Santos |
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In vivo treatment with Peroxisomal Proliferators reduces neuronal damage in a double transgenic model of Alzheimer's disease |
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| 4:15 - 4:30 |
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Cecile Brocard |
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A novel method to detect transient interactions with membrane bound peroxins |
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| 4:30 - 4:45 |
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Johannes Berger |
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Peroxisomal localization of beta-lipotropin and beta-endorphin in ALDP positive cells |
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| 4:45 - 5:00 |
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Q & A / Group discussion / Break |
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| 5:00 |
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Shuttles from ISB to Sheraton Hotel |
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| 6:00 - 9:00 |
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Welcome Reception |
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Sheraton Hotel |
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| 6:30 |
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Leroy Hood |
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The future and the promise of P4 Medicine |
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| 7:00 |
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Nancy Braverman |
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Introducing individuals with various peroxisome diseases and their families |
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Thursday, November 19th |
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| 8:00 |
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Shuttles from Sheraton Hotel to ISB |
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| 8:50 |
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Richard Rachubiniski |
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Day 2 - Opening Remarks |
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| 9:00 |
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Session: Peroxisome Biogenesis - Richard Rachubiniski (chair) |
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| 9:00 - 9:15 |
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Ramsey Saleem |
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Signaling controlling peroxisome biogenesis in yeast |
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| 9:15 - 9:30 |
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Jennifer Smith |
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Transcriptional control of oleate induced peroxisome biogenesis |
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| 9:30 - 9:45 |
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Ralf Erdmann |
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Dissection of the peroxisomal protein import machinery |
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| 9:45 - 10:00 |
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Yukio Fujiki |
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Peroxisome biogenesis and its regulation: membrane assembly, matrix protein import, and morphogenesis |
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| 10:00 - 10:15 |
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Hans Waterham |
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Genetic classification of > 600 patients with Zellweger Syndrome Spectrum disorder indicates 12 essential PEX genes |
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| 10:15 - 10:30 |
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Ewald Hettema |
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Multiple roles for Pex3 in peroxisome biogenesis |
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| 10:30 - 10:45 |
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Adabella van der Zand |
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Illuminating the yeast peroxisome biogenesis pathway |
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| 10:45 -11:15 |
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Q & A / Group Discussion / Break |
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| 11:15 - 11:30 |
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Sven Thoms |
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Evidence for Sec61 translocon involvement in peroxisome formation |
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| 11:30 - 11:45 |
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Fred Mast |
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Peroxisomal membrane protein biogenesis: insights from the polytopic integral membrane protein, Pex30p |
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| 11:45 - 12:00 |
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Arvind Jamakhandi |
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Peroxisomal Integral Membrane Proteins, Pex29 and Pex30, Interact with Resident Endoplasmic Reticulum Proteins |
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| 12:00 - 12:15 |
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Changle Ma |
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The peroxisomal matrix import of Pex8p requires only PTS receptors and Pex14p |
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| 12:15 - 12:30 |
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Hiroyuki Shibata |
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Structural-basis for the Pex3p-Pex19p interaction in the translocation of class I peroxisomal membrane proteins |
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| 12:30 - 12:45 |
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Markus Kunze |
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Mutational analysis of the PTS2-type peroxisomal targeting signal and the identification of novel human PTS2-targeted proteins |
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| 12:45 - 1:00 |
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Q & A / Group Discussion |
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| 1:00 - 2:30 |
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Lunch and Poster Session |
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| 2:30 - 2:45 |
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Sigrun Reumann |
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Large-scale machine learning models allow the prediction of new PTS1 signals of plant peroxisomes |
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| 2:45 - 3:00 |
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Matthias Wilmanns |
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Molecular principles in cargo recognition by the peroxisomal receptors and scaffold complexes |
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| 3:00 - 3:15 |
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Tsuneo Imanaka |
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Importance of the NH2-terminal hydrophobic motifs on the peroxisome selective targeting of PMP70 |
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| 3:15 - 3:30 |
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Shoji Mano |
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Isolation and characterization of Arabidopsis apm mutants that are defective in peroxisome biogenesis |
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| 3:30 - 3:45 |
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Markus Islinger |
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Hitchhiking of CU/ZN superoxide dismutase to peroxisomes - Evidence for a natural piggyback import mechanism in mammals |
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| 3:45 - 4:00 |
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Gregory Jedd |
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Woronin bodies: models of peroxisome and organelle differentiation |
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| 4:00 - 4:30 |
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Q & A / Group Discussion / Break |
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| 4:30 |
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Shuttles from ISB to Sheraton Hotel |
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Friday, November 20th |
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| 8:00 |
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Shuttles from Sheraton Hotel to ISB |
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| 8:50 |
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Suresh Subramani |
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Day 3 - Opening Remarks |
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| 9:00 |
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Session: Peroxisome Function - Suresh Subramani (chair) |
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| 9:00 - 9:15 |
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Myriam Baes |
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Peroxisomes, insulin sensitivity and thermogenesis: is there a link? |
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| 9:15 - 9:30 |
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Yasuyoshi Sakai |
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Peroxisome homeostasis in lower eukaryotes |
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| 9:30 - 9:45 |
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Ronald Wanders |
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New insights into the role of human ABCD1 and ABCD2 through studies in the yeast S. cerevisiae |
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| 9:45 - 10:00 |
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J. Kalervo Hiltunen |
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Metabolite traffic across peroxisomal membrane: Pxmp2 (PMP22) is a solute channel in mammals |
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| 10:00 - 10:15 |
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Anne-Marie Lamhonwah |
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The peroxisomal organic cation/ carnitine transporter OCTN3 |
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| 10:15 - 10:30 |
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Paul Michels |
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ABC transporters in the glycosomal membrane of Trypanosoma brucei are involved in fatty-acid uptake |
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| 10:30 - 10:45 |
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Vladimir Titorenko |
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Novel anti-aging small molecules greatly extend yeast life span by targeting a mechanism linking longevity and lipid metabolism in peroxisomes, the endoplasmic reticulum, and lipid bodies |
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| 10:45 - 11:15 |
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Q & A / Group Discussion / Break |
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| 11:15 |
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Session: Peroxisome Regulation - John Aitchison (chair) |
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| 11:15 - 11:30 |
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Andrei Fagarasanu |
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A feedback mechanism adjusts the level of Inp2p, the peroxisomal receptor for Myo2p, in response to peroxisome positioning in the dividing yeast cell |
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| 11:30- 11:45 |
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Jianping Hu |
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The role of three dynamin-related proteins and a tail-anchored protein in the division and positioning of peroxisomes in plants |
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| 11:45 - 12:00 |
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Wolfgang Schliebs |
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PEX14 is required for microtubule-based peroxisome motility in human cells |
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| 12:00 - 12:15 |
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Barbara Knoblach |
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Phosphorylation-dependent activation of peroxisome proliferator protein Pex11 controls peroxisome abundance |
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| 12:15 - 12:30 |
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Johannes-P. Koch |
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New aspects on the functional relationship between PEX11 and other factors of the peroxisomal proliferation machinery |
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| 12:30 - 1:00 |
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Q & A / Group Discussion / Break |
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| 1:00 - 2:30 |
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Lunch and Poster Session |
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| 2:30 - 2:45 |
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Peter Kim |
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NBR1 is required for peroxisome turnover in mammalian cells |
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| 2:45 - 3:00 |
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Marc Fransen |
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Formation and turnover of peroxisomes in cultured mammalian cells |
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| 3:00 - 3:15 |
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Ravi Manjithaya |
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Idenitifying new players required for selective autophagy of peroxisomes |
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| 3:15 - 3:30 |
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Bonnie Bartel |
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Peroxisome-associated matrix protein degradation in arabidopsis |
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| 3:30 - 3:45 |
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Heidi McBride |
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Identification of coats required for vesicle transport between mitochondria and peroxisomes |
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| 3:45 - 4:00 |
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Robert Mullen |
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The role of peroxisomes and ESCRT in tombusvirus replication |
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| 4:00 - 4:30 |
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Q & A / Group Discussion |
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| 4:30 - 4:40 |
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John Aitchison |
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Closing Remarks |
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| 5:00 |
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Shuttles from ISB to Sheraton Hotel |
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