Gene discovery for the system assignment of gene function

US Patent No: 
7,623,969
Issue Date: 
November 24, 2009
Inventors: 

Leroy E. Hood, Andrew F. Siegel, Troy E. Ideker

Abstract: 

The invention provides a method for assigning a cellular function to a component of a biochemical system. The method involves (a) determining a multidimensional shape space for one or more components of a biochemical system in a reference state; (b) perturbing a component within said biochemical system; (c) determining a perturbed multidimensional shape space for one or more components of a pathway in said perturbed biochemical system, and (d) identifying a multidimensional coordinate point corresponding to a component of said perturbed pathway altered between reference and perturbed multidimensional shape spaces, said identified component being assigned a cellular function of said perturbed pathway.

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