News

Under Seattle’s Cloud, a Big Data Cluster Grows

December 5, 2012

It’s a good time to be doing big data in Seattle.

So says Ed Lazowska, the University of Washington computer science professor who played host and tour guide to the region’s big data lineup during the Washington Innovation Summit last week. He points to the region’s strengths in cloud computing, and a steady stream of big data achievers marching forth from the UW.

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Lee Hood Named One of Top 13 Serial Entrepreneurs

November 13, 2012

Any business owner will tell you that it takes a lot of wits, energy, know-how, and no shortage of luck to found your own company. Many people have trouble getting one company off the ground, but then there are the special few who actually manage to found or co-found two, three, or even 19 companies in their lifetimes.

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Biology is a complex matter

November 8, 2012

Today’s grand chal­lenge in med­i­cine and biology is com­plexity, according to world-​​renowned sys­tems biol­o­gist Lee Hood, who addressed the North­eastern Uni­ver­sity com­mu­nity on Monday in the fourth install­ment in the Pro­files in Inno­va­tion Pres­i­den­tial Speaker Series.

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Sapphire Energy & Institute for Systems Biology Partner on Biofuels

November 1, 2012

San Diego’s Sapphire Energy and Seattle’s Institute for Systems Biology (ISB) have established a strategic partnership that is intended to significantly expand and diversify the genetic resources that Sapphire needs to commercialize algae-based biofuels.

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ISB's National Center for Systems Biology's Funding Renewed for $13.7 Million

October 17, 2012

NIGMS has also renewed funding for the NCSBs led by Arthur D. Lander, M.D., Ph.D., at the University of California, Irvine; and John D. Aitchison, Ph.D., at the Institute for Systems Biology under grants 2P50GM076516 and 2P50GM076547, respectively. (Note from ISB: ISB's renewal amounts to $13.7 million over five years.) The centers are exploring spatial dynamics and design principles in biology as well as the collective behavior of cells, cell differentiation and cellular responses to environmental changes.

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The New Genomic Bottleneck and How the Cloud Might Widen It

October 1, 2012

For years, the constraining factor in genomics research was data generation. The slowdown in the process or “bottleneck” was that generating genomic data required a great deal of time, specialized expertise and money. Scientists generated and read genomic sequence letter by letter. Because data were slowly generated, researchers had plenty of time to analyze them. However, in recent years, new technologies for genome sequencing have been developed.

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Study Divides Breast Cancer Into Four Distinct Types

September 24, 2012

ISB's Shmulevich lab was among the authors of this TCGA (The Cancer Genome Atlas) report on breast cancer.

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A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses

September 20, 2012

Antiviral responses must be tightly regulated to defend rapidly against infection while minimizing inflammatory damage. Type 1 interferons (IFN-I) are crucial mediators of antiviral responses

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Unlocking Brain Tumor Biology: Covance and ISB Collaborate

September 16, 2012

In March 2011, Covance’s Seattle-based Genomics Laboratory (CGL) collaborated with the Institute for Systems Biology (ISB), also based in Seattle, to collectively unravel the complex regulation of gene expression in Glioblastoma Multiforme (GBM), one of the most common and aggressive forms of brain cancer.

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Biotechs bring in flood of new execs

September 4, 2012

By Valerie Bauman, Puget Sound Business Journal --- Seattle’s biotech research nonprofits have been hiring — and not just scientists. With public research funding increasingly scarce and unpredictable, nonprofit research groups are bringing in new talent with fundraising as well as scientific skills.

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