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Mark Gillespie


Cardiovascular disease is the leading cause of death in North America. For atherosclerosis, plaque formation in arterial walls occurs as an inflammatory response to high cholesterol, with mature plaques at significant risk for rupture, which not only releases destructive inflammatory mediators into the circulatory system, but can also occlude major arteries resulting in heart attack or stroke. My research focuses on the transcriptional regulatory mechanisms controlling the macrophage response to metabolic changes associated with the progression of atherosclerosis.


Gillespie MA, Gold ES, Ramsey SA, Podolsky, I, Aderem A, and Ranish JA. (2015) An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux. The EMBO Journal. Epub 2015 Mar 9. pii: e201489819. PMID: 25755249

Scimé A, Soleimani VD, Bentzinger CF, Gillespie, MA, Le Grand F, Grenier G, Bevilacqua L, Harper ME, and Rudnicki MA. (2010) Oxidative status of muscle is determined by p107 regulation of PGC-1a. Journal of Cell Biology. 190:651-662. PMID: 20713602, PMCID: PMC2928004.

Gillespie MA, Le Grand F, Scime A, Kuang S, von Maltzahn J, Seale V, Cuenda A, Ranish JA, and Rudnicki MA. (2009) p38-{gamma}-dependent gene silencing restricts entry into the myogenic differentiation program. Journal of Cell Biology. 187:991-1005. PMID: 20026657, PMCID: PMC2806273.

Kuang S, Gillespie MA, and Rudnicki MA. (2008) Niche regulation of muscle satellite cell self-renewal and differentiation. Cell Stem Cell. 2:22-31. PMID: 18371418.

Scimé A, Grenier G, Huh MS, Gillespie MA, Bevilacqua L, Harper ME, and Rudnicki MA. (2005) Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metabolism. 2:283-295. PMID: 16271529.

Gillespie MA, and Rudnicki MA. (2004) Something to SNF about. Nature Genetics. 36:676-677. PMID: 15226749.

ISB Editorial Board: 
Member from August 2013 to Present