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The premise that the organ specific proteins in blood may be indicative of the diseased/perturbed networks of an organ holds promise in the assessment of organ health presymptomatically. To this end I am developing MRM driven mass spectrometric assays for organ specific proteins. Cancer stem cell (CSC) biology in the context of glioblastoma multiforme (GBM) is another area of my active research. Specific interests may include identification of membrane markers for CSC and understanding how CSC can harness tumor microenvironment in the process of tumorigenesis.
Ghosh, D., Lippert, D., Krokhin, O., Cortens, J.P., Wilkins, J.A. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom. 45(1):1-25. PMID:19946888
Ghosh, D., Beavis, R.C., Wilkins, J.A. (2008) The identification and characterization of membranome components. J Proteome Res. 7(4):1572-83. PMID: 18290606
Krokhin, O.V., Ying, S., Cortens, J.P., Ghosh, D., Spicer, V., Ens, W., Standing, K.G., Beavis, R.C., Wilkins, J.A.(2006) Use of peptide retention time prediction for protein identification by off-line reversed-phase HPLC-MALDI MS/MS. Anal Chem. 78(17):6265-9. PMID: 16944911
Ghosh, D., Krokhin, O., Antonovici, M., Ens, W., Standing, K.G., Beavis, R.C., Wilkin,s J.A.(2004) Lectin affinity as an approach to the proteomic analysis of membrane glycoproteins. J Proteome Res.3(4):841-50. PMID: 15359739