Boosting Signal-to-Noise in Complex Biology: Prior Knowledge Is Power

TitleBoosting Signal-to-Noise in Complex Biology: Prior Knowledge Is Power
Publication TypeJournal Article
Year of Publication2011
AuthorsIdeker T, Dutkowski J, Hood L
JournalCell
Volume144
Pagination860-3
Date PublishedMar 18
PMID21414478
AbstractA major difficulty in the analysis of complex biological systems is dealing with the low signal-to-noise inherent to nearly all large biological datasets. We discuss powerful bioinformatic concepts for boosting signal-to-noise through external knowledge incorporated in processing units we call filters and integrators. These concepts are illustrated in four landmark studies that have provided model implementations of filters, integrators, or both.

Back