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					The new technology, called Cell Surface Capture (CSC), uses mass spectrometry to identify cell surface proteins based on sugar molecules that are found coupled to most cell surface proteins. Watts and colleagues used the CSC technology to monitor changes in well over 300 cell surface proteins as stem cells transitioned to a neural cell type, all in a single experiment and without the need for antibodies. A lack of appropriate antibodies has limited the ability of scientists to conduct cell surface protein research. ISB authors include Bernd Wollscheid, Ruedi Aebersold and Julian D. Watts. Modification of software reduces protein analysis cost for small research institutes      The Trans-Proteomics Pipeline (TPP), a free, open-source software suite developed by researchers at ISB for high-throughput proteomic analysis, is now "cloud computing" ready. This enhancement has the potential to aid researchers in many institutes who are limited by cost barriers associated with technology infrastructure requirements.      Implemented by Insilicos LLC as part of a grant-funded collaboration with ISB, the changes enable scientists at smaller institutes to use TPP for large-scale research without the expensive server facilities required to process the massive data generated by high volume proteomics experiments. Changes to the TPP now allow the software to function remotely with data processed and stored on off-site processing "farms" (e.g. "on the cloud") available for rent from commercial organizations.
			Leap in cell surface protein detection could significantly impact diagnosis and treatment of disease      Detailed knowledge of proteins on cell surfaces is key to identifying different cell types and understanding how cells behave and interact with each other. ISB researchers recently published in Nature Biotechnology a new method that identifies more cell surface proteins by at least an order of magnitude than current best processes.      "This technology has the potential to significantly increase our understanding of virtually all aspects of human health and disease, including stem cell development, how cancers arise and how they progress, the functioning of the immune response to infectious disease, and tissue and organ repair following injury or damage," said Julian Watts, a senior research scientist at ISB who co-authored the work.
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