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My work in the Ozinsky lab focuses on applying novel single cell techniques to unravel the heterogeneity of breast cancer, which appear to be tightly associated with “cancer stem cells”, therapy relapse, and metastasis. Before my work at ISB I was a postdoc with Dr Chris Kemp at the Fred Hutchinson Cancer Research Center examining the role of tumor and metastasis suppressor genes in mouse tumor models. I received my PhD working in Dr. Peter Krammers lab in the Immunogenetics Department at the German Cancer Research Center (DKFZ) in Heidelberg, Germany, where I studied the role of receptor-mediated apoptosis.
Grosse-Wilde, A. and Kemp, C.J. Metastasis suppressor function of TRAIL-R in mice- implications for TRAIL-based therapy in humans? Cancer Research, Cancer Res. 2008 Aug 1;68(15):6035-7.
Grosse-Wilde, A., Voloshanenko, O., Bailey, S.L., Longton, G.M., Schaefer, U., Schütz, G., Greiner, E.F., Kemp, C.J. and Walczak, H. (2007) TRAIL-R deficiency enhances lymph node metastasis without affecting primary tumor development. J Clin Invest. 2008 Jan;118(1):100-10.
Herzer, K., Grosse-Wilde, A., Krammer, P.H., Galle, P.R., and Kanzler S. Functional Cooperation Between Smad Proteins and AP-1 Regulates TGF-ß–Mediated Induction of TRAIL in Hepatoma Cells. Molecular Cancer Research, Mol Cancer Res. 2008 Jul;6(7):1169-77.
Herzer, K., Ganten, T.M., Schulze-Bergkamen, H., Grosse-Wilde, A., Koschny, R., Krammer, P.H. and Walczak, H. (2005) Transforming growth factor beta can mediate apoptosis via the expression of TRAIL in human hepatoma cells. Hepatology, 42, 183-192.
Ganten, T.M., Haas, T.L., Sykora, J., Stahl, H., Sprick, M.R., Fas, S.C., Krueger, A., Weigand, M.A., Grosse-Wilde, A., Stremmel, W., Krammer, P.H. and Walczak, H. (2004) Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death Differ, 11 Suppl 1, S86-96.
Washburn B, Weigand MA, Grosse-Wilde A., Janke M, Stahl H, Rieser E, Sprick MR, Schirrmacher V, Walczak H. (2003) TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus. J Immunol. 2003 Feb 15;170(4):1814-21.
Sprick, M.R., Rieser, E., Stahl, H., Grosse-Wilde, A. and Walczak, H. (2002) Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signaling complexes in a FADD-dependent manner. EMBO J. 2002 Sep 2;21(17):4520-30.
Neufeld, B., Grosse-Wilde, A., Hoffmeyer, A., Jordan, B.W., Chen, P., Dinev, D., Ludwig, S. and Rapp, U.R. (2000) Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. J Biol Chem, 275, 20239-42.
Hoffmeyer, A.*, Grosse-Wilde, A.*, Flory, E., Neufeld, B., Kunz, M., Rapp, U.R. and Ludwig, S. (1999) Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor alpha gene expression in T lymphocytes. J Biol Chem, 274, 4319-27. * these authors contributed equally to this work
Dittrich, F., Ochs, G., Grosse-Wilde, A., Berweiler, U., Yan, Q., Miller, J.A., Toyka, K.V. and Sendtner, M. (1996) Pharmacokinetics of intrathecally applied BDNF and effects on spinal motoneurons. Exp Neurol, 141, 225-39.