In the Aebersold lab the following disciplines are represented:
- biology
- chemistry
- separation science/analytical chemistry
- computer science
- physics
The biologically and medically related research projects being pursued within the Aebersold laboratory, while being diverse, all strive to tackle key elements of human biology and disease. This approach is based upon the premise that the only truly useful technologies are those that can be demonstrably applied to a wide range of biologically and medically significant questions.
Researchers in the Aebersold lab, pursuing such questions, have available to them not only fully mature, high-throughput applications but experimental technologies still under development. As a result, the Aebersold lab research involves both proteomic technology development and actual proteomic research applications. This symbiotic relationship of mature and newly emerging technologies nurtures the development of powerful new approaches to biological investigation, unequaled almost anywhere worldwide.
Research
Unlike gene expression (array) analyses, proteomics is a broad and constantly changing field. Apart from their relative abundance, many other biologically important characteristics of proteins can be measured, including their:
- structure
- sub-cellular localization
- chemical modification
- interactions with other proteins
For most proteins, these characteristics cannot be readily predicted merely from prior knowledge of its respective gene or genome sequence. A proteomics—indeed systems biology—approach, is necessary. This is confirmed by the fact that, through global analyses of biological systems or diseases, new insights have emerged much more readily than they would have using traditional research approaches. This opens the door for the discovery of new markers for disease, ultimately leading to the development of new preventative and predictive clinical applications.
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