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Lee Rowen
Area of Expertise
Genomics
Current Position
Senior Research Scientist
Director, Sequencing Facility
Manager, Hood Laboratory
Degree
Ph.D., Biochemistry, Stanford University, 1977
Ph.D., Philosophy, Vanderbilt University, 1986
Research Interests
Dr. Rowen's research interests fall into the broad category of genomic landscapes: gene structure and organization, how genes are laid out along chromosomes, multigene families such as the vertebrate T cell receptor loci; comparative genomics; and sequencing technologies. As part of the International Human Genome Sequencing Consortium, she coordinated the effort to sequence major portions of chromosomes 14 and 15. She is also interested in the activity of building a scientific culture, asking questions such as: What fosters communication and interaction among scientists with different disciplinary training and worldviews? and, What do people need to have to be productive at different stages of their careers?
Selected Publications
Roach JC, Glusman G, Smit AF, Huff CD, Hubley R, Shannon PT, Rowen L, Pant KP, Goodman N, Bamshad M, Shendure J, Drmanac R, Jorde LB, Hood L, Galas DJ. 2010. Analysis of genetic inheritance in a family quartet by whole-genome sequencing. Science. 328:636-9. PMID: 20220176
David-Fung ES, Butler R, Buzi G, Yui MA, Diamond RA, Anderson MK, Rowen L, Rothenberg EV. 2009. Transcription factor expression dynamics of early T-lymphocyte specification and commitment. Dev Biol. 325:444-67. PMID: 19013443
Hood L, Rowen L, Galas DJ, Aitchison JD. 2008. Systems biology at the Institute for Systems Biology. 20 Brief Funct Genomic Proteomic. 7:239-48. PMID: 18579616
Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C. 2006. Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 440:671-675. PMID: 16572171
Cameron RA, Rowen L, (co-first authors) Nesbitt R, Bloom S, Rast JP, Berney K,
Arenas-Mena C, Martinez P, Lucas S, Richardson PM, Davidson EH, Peterson KJ,
Hood L. 2005. Unusual gene order and organization of the sea urchin hox cluster. J Exp
Zoolog B Mol Dev Evol. Aug 22; [Epub ahead of print]. PMID: 16116652
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