 |
|
Jared Roach
Area of Expertise
Computational Biology
Genetics
Genomics
Immunology
Current Position
Senior Research Scientist
Degree
Ph.D., Immunology, University of Washington, 1998
M.D. University of Washington, 1999
Research Interests
Dr. Roach is interested in basic and translational analyses and applications of high-throughput systems-biology data. He is currently focusing on understanding the genetics of complex neurodegenerative diseases, including Huntington's Disease. His research interests include analysis of MHC haplotypes and their relationship to risk and etiology of type 1 diabetes and other autoimmune diseases. Dr. Roach is pioneering approaches for the analysis of whole genome sequencing data in the context of family pedigrees.
His past studies have included (1) the systems biology of the macrophage, particularly in its role as an information processing device, at the levels of cell surface receptors, signal transduction, and nuclear regulation, (2) the molecular phylogenetics of vertebrate gene families, particularly those genes relevant to macrophage information processing, and (3) analysis and interpretation of transcript enumeration data, including RNAseq and microarray transcriptomics. Dr. Roach was a co-developer of the pairwise end-sequencing technique.
The translational impact of Dr. Roach's research contributes and has contributed to clinical areas including neurodegeneration, autoimmunity, rare genetic diseases, diabetes, inflammation, and vaccine development.
Selected Publications
Roach JC,* Glusman G,* Smit AFA,* Huff CD,* Hubley R, Shannon PT, Rowen L, Pant KP, Goodman N, Bamshad M, Shendure J, Drmanac R, Jorde LB, Hood L, Galas DJ. 2010. Analysis of genetic inheritance in a family quartet by whole genome sequencing. Science 328(5978):636-9. *Equal contributions.
Roach JC, Deutsch K, Li S, Siegel AF, Bekris LM, Einhaus DC, Sheridan CM, Glusman G, Hood L, Lernmark Ä, Janer M on behalf of the Swedish Childhood Diabetes Study Group and the Diabetes Incidence in Sweden Study Group. 2006. Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden. American Journal of Human Genetics 79(4):614-627.
Roach JC, Glusman G, Rowen L, Kaur A, Purcell MK, Smith KD, Hood L, Aderem A. 2005. The evolution of vertebrate toll-like receptors. Proc Natl Acad Sci U S A 102(27):9577-9582.
Roach JC, Glusman G, Rowen L, Kaur A, Purcell MK, Smith KD, Hood L, Aderem A. The evolution of vertebrate toll-like receptors. 2005. Proc Natl Acad Sci U S A 102(27):9577-82
Hubley RM, Zitzler E, Roach JC. Evolutionary algorithms for the selection of single nucleotide polymorphisms. 2003. BMC Bioinformatics 4(1):30. Software available at cvs.sourceforge.net/viewcvs.py/snp-magma/MAGMA.
Roach JC, Boysen C, Wang K, Hood L. Pairwise end sequencing: a unified approach to genomic mapping and sequencing. 1995 Genomics 26:345-353
Personal Web Page
http://www.strategicgenomics.com
|
|
|
home
