 |
|
Arian Smit
Area of Expertise
Genomics
Computational Biology
Current Position
Senior Research Scientist
Degree
Ph.D., Molecular Biology, University of Southern California, 1995
Research Interests
Dr. Smit's research activities focus on the evolution of transposable elements and their impact on the host, primarily through the study of the interspersed repetitive DNA these elements generate. He has co-created and is maintaining a database of such elements and has developed software to annotate and mask transposable element remnants in genomic DNA and to automatically produce repeat libraries for new genomes. Through these activities he has participated in "almost all" mammalian genome analysis projects. A continuous interest is the adoption by the genome of selfish elements as functional units and the subsequent creation of new regulatory networks. He currently further pursuits the study of neutral evolution patterns, the prediction of transcribed regions and phylogenetic analysis at the hand of interspersed repeats, and the reconstruction of an ancestral mammalian genome.
Selected Publications
Nishihara H, Smit AFA, Okada, N. Functional non-coding sequences derived from SINEs in the mammalian genome. 2006. Genome Res. 16(6)
Glusman G, Qin S, El-Gewely MR, Siegel AF, Roach JC, Hood L, Smit AFA. A Third Approach to Gene Prediction Suggests Thousands of Additional Human Transcribed Regions. 2006. PLoS Comput Biol. 2(3): e18
The International Human Genome Consortium. Initial sequencing and analysis of the human genome. 2001. Nature 409(6822):860-921
Smit AFA. Interspersed repeats and other mementos of transposable elements in the human genome. 1999. Curr. Opin. Genet. Devel. 9 (6):657-63
Smit AFA, Riggs AD. Tiggers and other DNA transposon fossils in the human genome. 1996. Proc. Natl. Acad. Sci. 93(4):1443-1448
Relevant Links
Smit AFA. (1996-2006) RepeatMasker. URL: http://www.repeatmasker.org
Jurka J & Smit AFA. (1994-2006) Reference collections of mammaian repetitive elements. URL: http://www.girinst.org/~server/repbase.html
|
|
|
home
