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Stephen Ramsey
Area of Expertise
Computational biology
Current Position
Senior Research Scientist
Degree
Ph.D, Physics, University of Maryland, 1997
Research Interests
Dr. Ramsey's research is focused on the macrophage foam cell, which is a key cell type in the development and progression of atherosclerosis. Specifically, Dr. Ramsey is using a systems biology approach to investigate transcriptional regulatory mechanisms underlying macrophage foam cell formation. Dr. Ramsey and his collaborators are integrating transcriptional measurements from an in vitro foam cell model with measurements from murine atherosclerotic plaque, to better understand the transcriptional changes underlying atherogenesis and atherosclerosis progression.
Selected Publications
Ramsey SA, Gold ES, Aderem A. 2010. A systems biology approach to understanding atherosclerosis. EMBO Mol Med. 2(3):79-89.
Litvak V, Ramsey SA, Rust AG, Zak DE, Kennedy KA, Lampano AE, Nykter M, Shmulevich I, Aderem A. 2009. Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat Immunol. 10(4):437-443.
Ramsey SA, Klemm SL, Zak DE, Kennedy KA, Thorsson V, Li B, Gilchrist M, Gold ES, Johnson CD, Litvak V, Navarro G, Roach JC, Rosenberger CM, Rust AG, Yudkovsky N, Aderem A, Shmulevich I. 2008. Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics. PLoS Comp Biol. 4(3):e100021.
Ramsey SA, Smith JJ, Orrell D, Marelli M, Petersen TW, de Atauri P, Bolouri H, Aitchison JD. 2006. Dual feedback loops in the GAL regulon suppress cellular heterogeneity in yeast. Nat Genet. 38(9):1082-1087.
Ramsey S, Orrell D, Bolouri H. 2005. Dizzy: stochastic simulation of large-scale genetic regulatory networks. J Bioinform Comput Biol. 3(2):415-436.
Relevant Links
Dizzy, a software program for simulating the stochastic dynamics of biochemical networks:
http://magnet.systemsbiology.net/software/Dizzy
Personal web page:
http://magnet.systemsbiology.net/sramsey/
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