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Pierre-Yves Bochud
Area of Expertise
Innate Immunogenetics
Current Position
Senior Research Scientist
Degree
MD, University of Lausanne, Switzerland 1995
Research Interests
After completing his clinical board in infectious diseases at the University Hospital of Lausanne, Switzerland, Dr. Pierre-Yves Bochud joined Dr. Alan Aderem's laboratory at the Institute for Systems Biology in 2001 to explore the immunogenetics of infectious diseases. His goal is to detect genetic markers that are associated with increased risk for infection. This issue is be particularly relevant for immunocompromised patients, such as those with HIV infection or those undergoing transplantation. Patients are at higher risk for specific pathogens may benefit from personalized and preventive measures, such as individualized surveillance, antimicrobial prophylaxis and/or specific vaccination programs.
Collaborators:
Dr. F. Negro, Swiss HCV Cohort Study
Dr. A. Telenti and P. Francioli, Swiss HIV Cohort Study
Dr. J. McElrath, Fred Hutchinson Cancer Research Center, Seattle WA (HIV)
Dr. M. Boeckh & L. Corey, Fred Hutchinson Cancer Research Center, Seattle WA (Infections in hematopoietic cell transplant recipients)
Dr. A. Wald & D. Koelle, University of Washington, Seattle WA (Herpes)
Dr. G. Kaplan, Public Health Research Institute, Newark NJ (Leprosy)
Dr. T. Calandra & T. Roger, University Hospital of Lausanne, Switzerland (Sepsis)
Dr. K. Mühlemann, University Hospital of Bern, Switzerland (Pneumococcal Infections)
Dr. M. Bochud, University of Lausanne, Switzerland (Genetic Epidemiology)
Dr. C. Stein, Case Western Reserve University, Cleveland OH (Genetic Epidemiology)
Selected Publications
Bochud PY, Bochud M, Telenti A and Calandra T. Innate Immunogenetics: A tool for exploring new frontiers of host defence. Lancet Infect Dis (in press).
Bochud PY, Magaret SA, Koelle D, Aderem A and Wald A. Polymorphisms in toll-like receptor 2 are associated with increased viral shedding and lesional rate in patients with genital HSV-2 infection. J Infect Dis (in press).
Bochud PY, Hersberger M, Taffé P, Bochud M, Stein CM, Rodrigues SD, Calandra T, Francioli P, Telenti A, Speck RF and Aderem A for The Swiss HIV Cohort Study. Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 Infection. 2007. AIDS 21:441-6.
Bochud PY and Calandra T. The pathogenesis of sepsis: new concepts and implications for future therapy. 2003. BMJ 26:262-6.
Bochud PY, Hawn T and Aderem A. A human Toll-like receptor-2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. 2003. J Immunol 170:3451-4.
Bochud PY, Eggiman P, Calandra T, Van Melle G, Saghafi L and Francioli P. Bacteremia due to viridans streptococcus in neutropenic patients with cancer: clinical spectrum and risk factors. 1994. Clin Infect Dis 18:25-31.
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