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Alan Diercks
Area of Expertise
Instrumentation, Microfluidics
Current Position
Senior Research Scientist
Degree
Ph.D., Physics, University of California, Santa Barbara, 1999
Research Interests
Dr. Diercks' research efforts are focused on the development of technologies for making both protein and nucleic-acid measurements on individual mammalian cells. In conjunction with the Aderem and Ozinsky groups, he has developed a microfluidic platform for measuring multiple proteins within nanoliter-scale volumes. His is currently working to apply this technology to measuring cytokine secretion profiles from single isolated macrophage cells.
Originally trained in experimental physics, he has extensive experience in the design and fabrication of electronic imaging systems, including several mosaic CCD camera systems. Since joining the Institute he has worked on a variety of instrumentation development efforts including microfabricated chips for the manipulation of single DNA molecules, a thermal ramping DNA microarray scanner for SNP genotyping, a spectrophotometer coupled to a high speed cell sorter to study dye uptake by bone-marrow stem cells, and a laser scanning system to study peptide mobility on IEF strip gels.
Selected Publications
Petersen TW, Ibrahim SF, Diercks AH, van den Engh G. Chromatic shifts in the fluorescence emitted by murine thymocytes stained with Hoechst 33342. 2004. Cytometry A 60(2):173-81
Asbury CL, Diercks AH, avan den Engh G.. Trapping of DNA by dielectrophoresis. 2002. Electrophroesis 23(16):2658—2666.
Riess AG, Filippenko AV, Challis P, Clocchiatti A, Diercks A, Garnavich PM,
Gilliland RL, Hogan CJ, Jha S, Kirshner RP, Leibundgut B, Phillips MM,
Reiss D, Schmidt BP, Schommer RA, Smith RC, Jspyromilio J, Stubbs C,
Suntzeff NB, Tonry J. Observational evidence from supernovae for an accelerating universe and a cosmological constant. 1998. AJ 116:1009—1038.
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