Dr. Ruedi Aebersold
Ph.D., Cellular Biology
University of Basel, Switzerland, 1983
Dr. Ruedi Aebersold, one of the pioneers in the field of proteomics, is known for developing a series of methods that have found wide application in analytical protein chemistry and proteomics. Most recently, his group developed a method for the rapid identification and accurate quantification of cellular proteins, i.e. for the generation of cellular "protein profiles";. The method is based on a new class of reagents termed Isotope Coded Affinity Tags or ICAT reagents, and mass spectrometry. Dr. Aebersold and his team of researchers use the "protein profiles" determined by the method to differentiate cells in different states, such as noncancerous vs. cancerous cells, and to systematically study how cells respond to external stimuli. These "snapshot" profiles indicate which cells contain abnormal levels of certain proteins. This is expected to lead to new diagnostic markers for disease and to a more complete understanding of the biochemical processes that control and constitute cell physiology.
Dr. Aebersold is a native of Switzerland and earned his Ph.D. in Cellular Biology at the Biocenter of the University of Basel in 1983. Since that time, he served on the faculties of the Universities of Washington and British Columbia, until 2000, when he co-founded the Institute for Systems Biology with Drs. Leroy Hood and Alan Aderem.
Dr. Aebersold also serves on the Scientific Advisory Committees of a number of academic and private sector research organizations and is a member of several editorial boards in the fields of protein science, genomics, and proteomics. Dr. Aebersold's research group and the ISB High Throughput Proteomics facility continue to refine robust proteomics technology and to identify and quantify thousands of proteins daily.
Awards
Dr. Aebersold's work using mass spectrometry to identify and characterize proteins has recently earned him several prestigious awards:
- The 2002 Biemann Medal , presented by the American Society of Mass Spectrometry, recognizes significant achievement in basic or applied mass spectrometry early in an individual's career.
- The 2002 Michael Widmer Award , presented by the Novartis Pharma and the Analytical Division of the Swiss Chemical Society at the HPLC 2002 Congress in Montreal, honors Aebersold's extraordinary and innovative contributions in analytical protein biochemistry and proteomics.
- 2002 Individual World Technology Award for Biotechnology recognizes innovative individuals who are contributing to the advance of emerging technologies for the benefit of business and society and who will likely become or remain key players in the technological drama unfolding in coming years.
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